Table 2 VDR gene polymorphism genotype and allele frequencies in the two study groups
SNP | MS (n = 50) | Controls (n = 50) | Significance | OR (95% CI) | ||
|---|---|---|---|---|---|---|
No. | % | No. | % | |||
FokI | ||||||
FF (wt) | 36 | 72.0 | 25 | 50.0 | χ2 = 6.33* | 0.42 (0.26–0.85) |
Ff (ht) | 14 | 28.0 | 22 | 44.0 | MCp = 0.029* | |
ff (mut) | 0 | 0.0 | 3 | 6.0 | ||
F | 86 | 86.0 | 72 | 72.0 | χ2 = 5.91* | |
f | 14 | 14.0 | 28 | 28.0 | P = 0.015* | |
BsmI | ||||||
BB (mut) | 20 | 40.0 | 22 | 44.0 | χ2 = 1.24 | 1.33 (0.76–2.32) |
Bb (ht) | 12 | 24.0 | 15 | 30.0 | P = 0.54 | |
bb (wt) | 18 | 36.0 | 13 | 26.0 | ||
B | 52 | 52.0 | 59 | 59.0 | χ2 = 0.99 | |
b | 48 | 48.0 | 41 | 41.0 | P = 0.32 | |
ApaI | ||||||
AA (mut) | 20 | 40.0 | 36 | 72.0 | χ2 = 11.103* | 2.47 (1.25–4.88) |
Aa (ht) | 28 | 56.0 | 12 | 24.0 | MCp = 0.002* | |
aa (wt) | 2 | 4.0 | 2 | 4.0 | ||
A | 68 | 68.0 | 84 | 84.0 | χ2 = 7.02* | |
a | 32 | 32.0 | 16 | 16.0 | P = 0.008* | |
TaqI | ||||||
TT (wt) | 24 | 48.0 | 18 | 36.0 | χ2 = 4.16 | 0.55 (0.31–0.98) |
Tt (ht) | 20 | 40.0 | 18 | 36.0 | P = 0.13 | |
tt (mut) | 6 | 12.0 | 14 | 28.0 | ||
T | 68 | 68.0 | 54 | 54.0 | χ2 = 4.12* | |
t | 32 | 32.0 | 46 | 46.0 | P = 0.04* | |
Tru9I | ||||||
UU (wt) | 28 | 56.0 | 37 | 74.0 | χ2 = 4.80 | 1.66 (0.82–3.35) |
Uu (ht) | 20 | 40.0 | 10 | 20.0 | MCp = 0.11 | |
uu (mut) | 2 | 4.0 | 3 | 6.0 | ||
U | 76 | 76.0 | 84 | 84.0 | χ2 = 2.0 | |
u | 24 | 24.0 | 16 | 16.0 | P = 0.16 | |