Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population

Egyptian Journal of Medical Human Genetics

Table 3 Pairwise linkage disequilibrium of VDR gene polymorphisms

	Variant 1	Variant 2	D′	P
Controls	FokI	BsmI	0.213	0.11
	FokI	Tru9I	0.045	0.76
	FokI	ApaI	0.392^*	0.012^*
	FokI	TaqI	0.471^*	0.002^*
	BsmI	Tru9I	0.258	0.18
	BsmI	ApaI	0.894^*	< 0.001^*
	BsmI	TaqI	− 0.265^*	0.017^*
	Tru9I	ApaI	0.033	0.74
	Tru9I	TaqI	0.074	0.73
	ApaI	TaqI	0.389	0.07
MS	FokI	BsmI	− 0.099	0.68
	FokI	Tru9I	0.060	0.74
	FokI	ApaI	0.370	0.06
	FokI	TaqI	0.160	0.37
	BsmI	Tru9I	0.199	0.25
	BsmI	ApaI	0.519^*	< 0.001^*
	BsmI	TaqI	− 0.202	0.15
	Tru9I	ApaI	0.265^*	0.03^*
	Tru9I	TaqI	0.044	0.87
	ApaI	TaqI	0.081	0.42

D′ normalized linkage disequilibrium coefficient D values normally range from − 1 to 1, where values close to − 1 or 1 indicate high polymorphism linkage on one allele
^*Significant at P ≤ 0.05