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Table 3 Pairwise linkage disequilibrium of VDR gene polymorphisms

From: Protective association of VDR gene polymorphisms and haplotypes with multiple sclerosis patients in Egyptian population

  Variant 1 Variant 2 D P
Controls FokI BsmI 0.213 0.11
FokI Tru9I 0.045 0.76
FokI ApaI 0.392* 0.012*
FokI TaqI 0.471* 0.002*
BsmI Tru9I 0.258 0.18
BsmI ApaI 0.894* < 0.001*
BsmI TaqI − 0.265* 0.017*
Tru9I ApaI 0.033 0.74
Tru9I TaqI 0.074 0.73
ApaI TaqI 0.389 0.07
MS FokI BsmI − 0.099 0.68
FokI Tru9I 0.060 0.74
FokI ApaI 0.370 0.06
FokI TaqI 0.160 0.37
BsmI Tru9I 0.199 0.25
BsmI ApaI 0.519* < 0.001*
BsmI TaqI − 0.202 0.15
Tru9I ApaI 0.265* 0.03*
Tru9I TaqI 0.044 0.87
ApaI TaqI 0.081 0.42
  1. D′ normalized linkage disequilibrium coefficient D values normally range from − 1 to 1, where values close to − 1 or 1 indicate high polymorphism linkage on one allele
  2. *Significant at P ≤ 0.05