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Table 10 Genotype distribution of MTHFR and serum levels of vitamin B12, folate, and homocysteine in DSM and CM

From: MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

Serum CM DSM
CC CT CC CT
Vitamin B12 383.9 ± 49.35 375.5 ± 41.14NS 232.3 ± 28.11# 121.4 ± 10.11***++
Folic acid 6.444 ± 0.6534 4.117 ± 0.6469NS 3.578 ± 0.3562## 2.044 ± 0.2161*++
Homocysteine 4.11 ± 1.116 17.05 ± 2.979NS 20.38 ± 2.329### 32.53 ± 3.878**+++
  1. #CM vs DSM (CC/CC), #p < 0.05), ##p < 0.01, ###p < 0.001
  2. *CM Vs DSM (CT/CT), *p < 0.05, **p < 0.01, ***p < 0.001
  3. +DSM (CC Vs CT), +p < 0.05), ++p < 0.01, +++p < 0.001, NS CM (CC/CT), not significant