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Table 4 Genotype distribution of MTHFR in DSM and Congenital heart disease (CHD) in the DS child

From: MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

Genotype DSM group
No CHD
n, f(%)
CHD
n, f(%)
OR (CI) p value
CC 29 (25.2) 12 (10.43) Reference Reference
CT 13 (11.3) 61 (53.0) 11.34 (4.6 to27.9) p < 0.001***
  1. n number of genotype, f frequency, OR odds ratio, CI 95% confidence interval
  2. ***p < 0.001