Table 1 Response categories according to ELN AML recommendations guidelines
Category Response | Definition | Comment |
|---|---|---|
CR without minimal residual disease (CRMRD-) | If studied pretreatment, CR with negativity for a genetic marker by RT-qPCR or CR with negativity by MFC | Sensitivities vary by marker tested and by method used; therefore, test used and sensitivity of the assay should be reported; analyses should be done in experienced laboratories (centralized diagnostics) |
Complete remission (CR) | Bone marrow blasts < 5%, absence of circulating blasts and blasts with Auer rods, absence of extramedullary disease, ANC ≥ 1 × 109/L; platelet count ≥ 100 × 109/L | MRD+ or unknown |
CR with incomplete hematologic recovery (CRi) | All CR criteria except for residual neutropenia (< 1 × 109/L) or thrombocytopenia (< 100 × 109/L) | |
Morphologic leukemia-free state (MLFS) | Bone marrow blasts < 5%, absence of blasts with Auer rods, absence of extramedullary disease, no hematologic recovery required | Marrow should not merely be “aplastic”; at least 200 cells should be enumerated or cellularity should be at least 10% |
Partial remission (PR) | All hematologic criteria of CR, decrease of bone marrow blast percentage to 5–25%, and decrease of pretreatment bone marrow blast percentage by at least 50% | Especially important in the context of phase 1–2 clinical trials |