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Table 3 Comparison between normal and mutant IDH1 SNP rs11554137 patients

From: Prognostic implications of IDH1rs11554137 and IDH2R140Q SNPs mutations in cytogenetically normal acute myeloid leukemia

   Normal IDH1SNP
(N = 69, 86.2%)
Heterozygous IDH1SNP mutation
(N = 11, 13.8%)
p value*#
Age (years) Mean ± SD 42.1 ± 14.2 62.3 ± 15.7 < 0.001
Gender N (%)    
 Male   50 (72.5) 6 (54.5) 0.228
 Female   19 (27.5) 5 (45.5)  
Hepatomegaly N (%)    
 Negative   36 (52.2) 7 (63.6) 0.479
 Positive   33 (47.8) 4 (36.4)  
Splenomegaly N (%)    
 Negative   23 (33.3) 6 (54.5) 0.174
 Positive   46 (66.7) 5 (45.5)  
Lymphadenopathy N (%)    
 Negative   44 (63.8) 10 (90.9) 0.074
 Positive   25 (36.2) 1 (9.1)  
Hemoglobin (g/dl) Mean ± SD 6.7 ± 1.7 7.3 ± 1.0 0.260
TLC (× 109/L) Mean ± SD 68.4 ± 39 72.7 ± 58.7 0.754
Platelets (× 109/L) Mean ± SD 26.6 ± 16.2 48.1 ± 9.2 < 0.001
Blast cells (%) Mean ± SD 69.6 ± 16.1 87.8 ± 6.3 < 0.001
FAB classification N (%)    0.099
 M1   10 (14.5) 4 (36.4)  
 M2   37 (53.6) 7 (63.6)  
 M4   16 (23.2) 0 (0)  
 M5   6 (8.7) 0 (0)  
IDH2R140Q N (%)    0.488
 Normal   57 (82.6) 10 (90.9)  
 Heterozygous   12 (17.4) 1 (9.1)  
Outcome at 28 days N (%)    0.054
 Favorable+   18 (26.1) 0 (0)  
 Unfavorable++   51 (73.9) 11 (100)  
Outcome at 6 months N (%)    0.003
 Favorable+   33 (47.8) 0 (0)  
 Unfavorable+++   36 (52.2) 11(100)  
Median survival (days) Median (IQR) 170 (27–170) 12 (8–20) < 0.0001
  1. N number, SD standard deviation, TLC total leucocytic count, IQR interquartile range
  2. *Unpaired t test for quantitative data with parametric distribution
  3. #Chi-square test for qualitative data
  4. Fisher’s exact test when the expected count in any cell was found at less than 5
  5. +Favorable outcome = CR (complete remission)
  6. ++Unfavorable outcome = D (dead) or PR (partial remission)
  7. +++Unfavorable outcome = D (dead) or R (relapse)
  8. A p value <0.05 was considered the cut-off value for significance in all analyses