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Table 3 Comparison between normal and mutant IDH1 SNP rs11554137 patients

From: Prognostic implications of IDH1rs11554137 and IDH2R140Q SNPs mutations in cytogenetically normal acute myeloid leukemia

  

Normal IDH1SNP

(N = 69, 86.2%)

Heterozygous IDH1SNP mutation

(N = 11, 13.8%)

p value*#

Age (years)

Mean ± SD

42.1 ± 14.2

62.3 ± 15.7

< 0.001

Gender

N (%)

   

 Male

 

50 (72.5)

6 (54.5)

0.228

 Female

 

19 (27.5)

5 (45.5)

 

Hepatomegaly

N (%)

   

 Negative

 

36 (52.2)

7 (63.6)

0.479

 Positive

 

33 (47.8)

4 (36.4)

 

Splenomegaly

N (%)

   

 Negative

 

23 (33.3)

6 (54.5)

0.174

 Positive

 

46 (66.7)

5 (45.5)

 

Lymphadenopathy

N (%)

   

 Negative

 

44 (63.8)

10 (90.9)

0.074

 Positive

 

25 (36.2)

1 (9.1)

 

Hemoglobin (g/dl)

Mean ± SD

6.7 ± 1.7

7.3 ± 1.0

0.260

TLC (× 109/L)

Mean ± SD

68.4 ± 39

72.7 ± 58.7

0.754

Platelets (× 109/L)

Mean ± SD

26.6 ± 16.2

48.1 ± 9.2

< 0.001

Blast cells (%)

Mean ± SD

69.6 ± 16.1

87.8 ± 6.3

< 0.001

FAB classification

N (%)

  

0.099

 M1

 

10 (14.5)

4 (36.4)

 

 M2

 

37 (53.6)

7 (63.6)

 

 M4

 

16 (23.2)

0 (0)

 

 M5

 

6 (8.7)

0 (0)

 

IDH2R140Q

N (%)

  

0.488

 Normal

 

57 (82.6)

10 (90.9)

 

 Heterozygous

 

12 (17.4)

1 (9.1)

 

Outcome at 28 days

N (%)

  

0.054

 Favorable+

 

18 (26.1)

0 (0)

 

 Unfavorable++

 

51 (73.9)

11 (100)

 

Outcome at 6 months

N (%)

  

0.003

 Favorable+

 

33 (47.8)

0 (0)

 

 Unfavorable+++

 

36 (52.2)

11(100)

 

Median survival (days)

Median (IQR)

170 (27–170)

12 (8–20)

< 0.0001

  1. N number, SD standard deviation, TLC total leucocytic count, IQR interquartile range
  2. *Unpaired t test for quantitative data with parametric distribution
  3. #Chi-square test for qualitative data
  4. Fisher’s exact test when the expected count in any cell was found at less than 5
  5. +Favorable outcome = CR (complete remission)
  6. ++Unfavorable outcome = D (dead) or PR (partial remission)
  7. +++Unfavorable outcome = D (dead) or R (relapse)
  8. A p value <0.05 was considered the cut-off value for significance in all analyses