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Table 4 Comparison between normal and mutant IDH2R140Q patients

From: Prognostic implications of IDH1rs11554137 and IDH2R140Q SNPs mutations in cytogenetically normal acute myeloid leukemia

  

Normal IDH2R140Q

(N = 67, 83.7%)

Heterozygous IDH2R140Q mutation

(N = 13, 16.3%)

p value*#

Age (years)

Mean ± SD

42.6 ± 16.0

57.2 ± 8.5

0.002

Gender

N (%)

  

0.950

 Male

 

47 (70.1)

9 (69.3)

 

 Female

 

20 (29.9)

4 (30.7)

 

Hepatomegaly

N (%)

  

0.221

 Negative

 

34 (50.7)

9 (69.3)

 

 Positive

 

33 (49.3)

4 (30.7)

 

Splenomegaly

N (%)

  

0.149

 Negative

 

22 (32.8)

7 (53.8)

 

 Positive

 

45 (67.2)

6 (46.2)

 

Lymphadenopathy

N (%)

  

0.037

 Negative

 

42 (62.7)

12 (92.3)

 

 Positive

 

25 (37.3)

1 (7.7)

 

Hemoglobin (g/dl)

Mean ± SD

6.7 ± 1.5

7.3 ± 2.2

0.228

TLC (× 109/L)

Mean ± SD

77.9.4 ± 39.1

22.2 ± 15.6

< 0.001

Platelets (× 109/L)

Mean ± SD

25.9 ± 13.2

49.1 ± 22.7

< 0.001

Blast cells (%)

Mean ± SD

70.4 ± 21.0

81.3 ± 7.4

0.069

FAB classification

N (%)

  

0.439

 M1

 

11 (16.4)

0 (0)

 

 M2

 

35 (52.2)

9 (69.2)

 

 M4

 

16 (23.8)

3 (23.1)

 

 M5

 

5 (7.6)

1 (7.7)

 

IDH1SNPrs11554137

N (%)

  

0.488

 Normal

 

57 (85.1)

12 (92.3)

 

 Heterozygous

 

10 (14.9)

1 (7.7)

 

Outcome at 28 days

N (%)

  

0.010

 Favorable+

 

18 (26.9)

0 (0)

 

 Unfavorable++

 

49 (73.1)

13 (100)

 

Outcome at 6 months

N (%)

  

0.146

 Favorable+

 

30 (44.8)

3 (23.1)

 

 Unfavorable+++

 

37 (55.2)

10 (76.9)

 

Median survival (days)

Median (IQR)

160 (25–170)

14 (9–55)

0.027

  1. N number, SD standard deviation, TLC total leucocytic count, IQR interquartile range
  2. *Unpaired t test for quantitative data with parametric distribution
  3. #Chi-square test for qualitative data
  4. Fisher’s exact test when the expected count in any cell was found at less than 5
  5. +Favorable outcome = CR (complete remission)
  6. ++Unfavorable outcome = D (dead) or PR (partial remission)
  7. +++Unfavorable outcome = D (dead) or R (relapsed)
  8. A p value <0.05 was considered the cut-off value for significance in all analyses