Egyptian Journal of Medical Human Genetics

Table 6 APOE rs4420638 polymorphism and cardiometabolic risk

From: Association study of APOE gene polymorphisms with diabetes and the main cardiometabolic risk factors, in the Algerian population

rs4420638	Major allele/minor allele	ISOR
		Genotypes (N) p		OR [95% CI] p	OR^* [95% CI] p
T2D	A/G	Control	Case	AG vs AA: 1.20 [0.65–2.22] p = 0.56	0.99 [0.56–1.75] p = 0.98
		AA (515) AG(124) GG (9)	AA (63) AG(16) GG (0)
		p = 0.56
Obesity	A/G	AA (463) AG (128) GG (10)	AA (136) AG (21) GG (0)	AG vs AA: 0.51 [0.30–0.85] p = 0.01*	0.48[0.29–0.79] p = 0.004*
Obesity	A/G	p = 0.02		AG vs AA: 0.51 [0.30–0.85] p = 0.01*	0.48[0.29–0.79] p = 0.004*
MetS	A/G	AA (473) AG (118) GG (7)	AA (117) AG (27) GG (3)	AG vs AA: 0.93 [0.57–1.53] p = 0.78 GG vs AA: 3.19 [0.73–13.89] p = 0.12	1.10 [0.71–1.70] p = 0.66
MetS	A/G	p = 0.68			1.10 [0.71–1.70] p = 0.66
HBP	A/G	AA (469) AG (128) GG (7)	AA (20) AG (127) GG (3)	AG vs AA: 0.56 [0.33–0.96] p = 0.03 GG vs AA: 2.24 [0.51–9.84] p = 0.29	0.73 [0.47–1.14] p = 0.17
HBP	A/G	p < 0.001

T2D type 2 diabetes, MetS metabolic syndrome, HBP high blood pressure. OR adjusted on age, gender, physical activity, and smoking status. OR* obtained for additive model. p values were adjusted for age, gender, physical activity, and smoking status. Significant p values are indicated in italics with an asterisk

Back to article page