No. | Allele and genotype | Parameters | Overall | Continent | Genotyping | ||||
---|---|---|---|---|---|---|---|---|---|
Europe | America | Asia | Africa | PCR | PCR-RFLP | ||||
1 | A vs. C | OR | 0.84 | 0.88 | 0.94 | 0.78 | 0.89 | 0.95 | 0.77 |
95%CI | 0.75–0.97 | 0.72–1.08 | 0.52–1.67 | 0.64–0.96 | 0.54–1.48 | 0.85–1.07 | 0.61–0.96 | ||
p | 0.0130 | 0.2320 | 0.8190 | 0.0190 | 0.6620 | 0.4250 | 0.0190 | ||
pH | < 0.0001 | < 0.0001 | 0.0020 | < 0.0001 | 0.0030 | 0.0200 | < 0.0001 | ||
pE | 0.3580 | 0.3390 | 0.5000 | 0.3670 | 0.5150 | 0.1640 | 0.4820 | ||
2 | C vs. A | OR | 1.18 | 1.13 | 1.07 | 1.27 | 1.12 | 1.05 | 1.31 |
95%CI | 1.04–1.34 | 0.92–1.38 | 0.60–1.91 | 1.04–1.55 | 0.68–1.85 | 0.93–1.18 | 1.05–1.63 | ||
p | 0.0130 | 0.2320 | 0.8190 | 0.0190 | 0.6620 | 0.4250 | 0.0190 | ||
pH | < 0.0001 | < 0.0001 | 0.0020 | < 0.0001 | 0.0030 | 0.0200 | < 0.0001 | ||
pE | 0.3580 | 0.3390 | 0.5000 | 0.3670 | 0.5150 | 0.1640 | 0.4820 | ||
3 | AA vs. AC + CC | OR | 0.82 | 0.85 | 0.86 | 0.77 | 0.89 | 0.93 | 0.74 |
95%CI | 0.71–0.94 | 0.68–1.07 | 0.47–1.57 | 0.62–0.95 | 0.54–1.47 | 0.84–1.02 | 0.58–0.95 | ||
p | 0.0050 | 0.1710 | 0.6320 | 0.0160 | 0.6570 | 0.1060 | 0.0160 | ||
pH | < 0.0001 | < 0.0001 | 0.0090 | < 0.0001 | 0.0250 | 0.1050 | < 0.0001 | ||
pE | 0.3760 | 0.3700 | 0.5050 | 0.3980 | 0.4810 | 0.1440 | 0.5280 | ||
4 | AC vs. AA + CC | OR | 1.15 | 1.11 | 1.20 | 1.19 | 1.09 | 1.10 | 1.20 |
95%CI | 1.04–1.28 | 0.95–1.29 | 0.91–1.57 | 1.01–1.41 | 0.85–1.38 | 1.00–1.21 | 1.01–1.43 | ||
p | 0.0060 | 0.2030 | 0.1910 | 0.0410 | 0.5050 | 0.0490 | 0.0430 | ||
pH | 0.0010 | 0.0490 | 0.1520 | 0.0030 | 0.2550 | 0.5280 | < 0.0001 | ||
pE | 0.2110 | 0.1860 | 0.2620 | 0.2570 | 0.2210 | < 0.0001 | 0.3210 | ||
5 | CC vs. AA + AC | OR | 1.14 | 1.07 | 0.88 | 1.81 | 0.78 | 0.91 | 1.53 |
95%CI | 0.88–1.48 | 0.74–1.56 | 0.49–1.57 | 1.38–2.36 | 0.46–1.32 | 0.73–1.15 | 1.02–2.28 | ||
p | 0.3310 | 0.7190 | 0.6600 | < 0.0001 | 0.3530 | 0.4410 | 0.0390 | ||
pH | 0.0010 | 0.0060 | 0.1350 | 0.2640 | 0.1210 | 0.3140 | 0.0060 | ||
pE | 0.4910 | 0.5030 | 0.9310 | 0.2770 | 0.6170 | 0.1810 | 0.5520 |