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Table 2 Summary of analysis concerning the association between AT1R A1166C gene polymorphism and the risk of essential hypertension

From: The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

No. Allele and genotype Parameters Overall Continent Genotyping
Europe America Asia Africa PCR PCR-RFLP
1 A vs. C OR 0.84 0.88 0.94 0.78 0.89 0.95 0.77
95%CI 0.75–0.97 0.72–1.08 0.52–1.67 0.64–0.96 0.54–1.48 0.85–1.07 0.61–0.96
p 0.0130 0.2320 0.8190 0.0190 0.6620 0.4250 0.0190
pH < 0.0001 < 0.0001 0.0020 < 0.0001 0.0030 0.0200 < 0.0001
pE 0.3580 0.3390 0.5000 0.3670 0.5150 0.1640 0.4820
2 C vs. A OR 1.18 1.13 1.07 1.27 1.12 1.05 1.31
95%CI 1.04–1.34 0.92–1.38 0.60–1.91 1.04–1.55 0.68–1.85 0.93–1.18 1.05–1.63
p 0.0130 0.2320 0.8190 0.0190 0.6620 0.4250 0.0190
pH < 0.0001 < 0.0001 0.0020 < 0.0001 0.0030 0.0200 < 0.0001
pE 0.3580 0.3390 0.5000 0.3670 0.5150 0.1640 0.4820
3 AA vs. AC + CC OR 0.82 0.85 0.86 0.77 0.89 0.93 0.74
95%CI 0.71–0.94 0.68–1.07 0.47–1.57 0.62–0.95 0.54–1.47 0.84–1.02 0.58–0.95
p 0.0050 0.1710 0.6320 0.0160 0.6570 0.1060 0.0160
pH < 0.0001 < 0.0001 0.0090 < 0.0001 0.0250 0.1050 < 0.0001
pE 0.3760 0.3700 0.5050 0.3980 0.4810 0.1440 0.5280
4 AC vs. AA + CC OR 1.15 1.11 1.20 1.19 1.09 1.10 1.20
95%CI 1.04–1.28 0.95–1.29 0.91–1.57 1.01–1.41 0.85–1.38 1.00–1.21 1.01–1.43
p 0.0060 0.2030 0.1910 0.0410 0.5050 0.0490 0.0430
pH 0.0010 0.0490 0.1520 0.0030 0.2550 0.5280 < 0.0001
pE 0.2110 0.1860 0.2620 0.2570 0.2210 < 0.0001 0.3210
5 CC vs. AA + AC OR 1.14 1.07 0.88 1.81 0.78 0.91 1.53
95%CI 0.88–1.48 0.74–1.56 0.49–1.57 1.38–2.36 0.46–1.32 0.73–1.15 1.02–2.28
p 0.3310 0.7190 0.6600 < 0.0001 0.3530 0.4410 0.0390
pH 0.0010 0.0060 0.1350 0.2640 0.1210 0.3140 0.0060
pE 0.4910 0.5030 0.9310 0.2770 0.6170 0.1810 0.5520
  1. PCR polymerase chain reaction, PCR-RFLP PCR-restriction fragment length polymorphism, OR odds ratio, CI confidence interval, pH p heterogeneity, pE p Egger