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Table 2 Summary of analysis concerning the association between AT1R A1166C gene polymorphism and the risk of essential hypertension

From: The association between angiotensin II type 1 receptor A1166C gene polymorphism and the risk of essential hypertension: a meta-analysis

No.

Allele and genotype

Parameters

Overall

Continent

Genotyping

Europe

America

Asia

Africa

PCR

PCR-RFLP

1

A vs. C

OR

0.84

0.88

0.94

0.78

0.89

0.95

0.77

95%CI

0.75–0.97

0.72–1.08

0.52–1.67

0.64–0.96

0.54–1.48

0.85–1.07

0.61–0.96

p

0.0130

0.2320

0.8190

0.0190

0.6620

0.4250

0.0190

pH

< 0.0001

< 0.0001

0.0020

< 0.0001

0.0030

0.0200

< 0.0001

pE

0.3580

0.3390

0.5000

0.3670

0.5150

0.1640

0.4820

2

C vs. A

OR

1.18

1.13

1.07

1.27

1.12

1.05

1.31

95%CI

1.04–1.34

0.92–1.38

0.60–1.91

1.04–1.55

0.68–1.85

0.93–1.18

1.05–1.63

p

0.0130

0.2320

0.8190

0.0190

0.6620

0.4250

0.0190

pH

< 0.0001

< 0.0001

0.0020

< 0.0001

0.0030

0.0200

< 0.0001

pE

0.3580

0.3390

0.5000

0.3670

0.5150

0.1640

0.4820

3

AA vs. AC + CC

OR

0.82

0.85

0.86

0.77

0.89

0.93

0.74

95%CI

0.71–0.94

0.68–1.07

0.47–1.57

0.62–0.95

0.54–1.47

0.84–1.02

0.58–0.95

p

0.0050

0.1710

0.6320

0.0160

0.6570

0.1060

0.0160

pH

< 0.0001

< 0.0001

0.0090

< 0.0001

0.0250

0.1050

< 0.0001

pE

0.3760

0.3700

0.5050

0.3980

0.4810

0.1440

0.5280

4

AC vs. AA + CC

OR

1.15

1.11

1.20

1.19

1.09

1.10

1.20

95%CI

1.04–1.28

0.95–1.29

0.91–1.57

1.01–1.41

0.85–1.38

1.00–1.21

1.01–1.43

p

0.0060

0.2030

0.1910

0.0410

0.5050

0.0490

0.0430

pH

0.0010

0.0490

0.1520

0.0030

0.2550

0.5280

< 0.0001

pE

0.2110

0.1860

0.2620

0.2570

0.2210

< 0.0001

0.3210

5

CC vs. AA + AC

OR

1.14

1.07

0.88

1.81

0.78

0.91

1.53

95%CI

0.88–1.48

0.74–1.56

0.49–1.57

1.38–2.36

0.46–1.32

0.73–1.15

1.02–2.28

p

0.3310

0.7190

0.6600

< 0.0001

0.3530

0.4410

0.0390

pH

0.0010

0.0060

0.1350

0.2640

0.1210

0.3140

0.0060

pE

0.4910

0.5030

0.9310

0.2770

0.6170

0.1810

0.5520

  1. PCR polymerase chain reaction, PCR-RFLP PCR-restriction fragment length polymorphism, OR odds ratio, CI confidence interval, pH p heterogeneity, pE p Egger