Parameters

PAI1 genotypes in DM with VCs

P value


5G/5G (n = 8)

4G/5G (n = 47)

4G/4G (n = 28)


Age (years) (mean ± SD)

48.00 ± 5.76

49.06 ± 6.89

48.43 ± 5.95

0.867^{NS, 1}

Gender [n (%)]
   
0.933 ^{NS, 2}

Male

6 (75.0)

35 (74.5)

20 (71.4)
 
Female

2 (25.0)

12 (25.5)

8 (28.6)
 
Smoking [n (%)]
   
< 0.001 ^{HS,2}

No

7 (87.5)

25 (53.2)

27 (96.4)
 
Yes

1 (12.5) _{a, b}

22 (46.8) _{b}

1 (3.6) _{a}
 
Dyslipidemia [n (%)]
   
0.096 ^{NS, 2}

Absent

1 (12.5)

0 (0.0)

0 (0.0)
 
Present

7 (87.5)

47 (100.0)

28 (100.0)
 
Hypertension [n (%)]
   
0.385 ^{NS, 2}

Absent

2 (25.0)

5 (10.6)

4 (14.3)
 
Present

6 (75.0)

42 (89.4)

24 (85.7)
 
Duration of DM (years)

4.0 (2.9)

3.8 (3.8)

3.60 (2.23)

0.729 ^{NS, 3}

PAI1

26.5 (6.25)_{a}

65.0 (10.0)_{b}

48.5 (11)_{c}

< 0.001 ^{HS, 3}

TAFI

46.5 (14.5)_{a}

115.0 (42.0)_{b}

74 (24)_{a}

< 0.001 ^{HS, 3}

ddimer (mg/dl)

0.70 (0.20)_{a}

2.90 (0.80)_{b}

1.40 (0.98)_{c}

< 0.001 ^{HS, 3}

BMI (kg/m^{3})

27.20 (2.15)_{a,b}

31.20 (5.40)_{a}

26.70 (2.65)_{b}

< 0.001 ^{HS, 3}

SBP (mmHg)

120.0 (32.50)_{a, b}

155.0 (40.0)_{a}

120 (17.0)_{b}

0.001 ^{HS, 3}

DBP (mmHg)

80 (20.50)_{a,b}

94 (26.00)_{a}

82 (10.0) _{b}

0.004 ^{HS, 3}

FBS (mg/dl)

122.5 (17.25)_{a, b}

145 (47)_{a}

121.50 (21.25)_{b}

0.027 ^{S, 3}

2Hr BS (mg/dl)

146.0 (18.5)

167.0 (55.0)

148.50 (34.75)

0.078 ^{NS, 3}

HbA1c (%)

7.0 (1.30)

8.0 (2.40)

7.20 (0.98)

0.055 ^{NS, 3}

T. C (mg/dl)

187.5 (21.75)_{a}

198.0 (22.0)_{b}

197.50 (35.00)_{a, b}

0.024 ^{S, 3}

Triglycerides (mg/dl)

151.5 (12.5)_{a}

170.0 (35.0)_{b}

166.0 (29.25)_{b}

< 0.001 ^{HS, 3}

LDL (mg/dl) (mean ± SD)

116.83 ± 8.55

130.11 ± 18.38

121.93 ± 21.33

0.084 ^{NS, 1}

HDL (mg/dl) (mean ± SD)

36.25 ± 5.18

37.09 ± 5.42

39.57 ± 4.03

0.077 ^{NS, 1}

 Values are expressed as median (IQR) unless otherwise indicated; % percent within genotype subgroup
 ^{1}ANOVA test, adjusted for multiple pairwise comparisons by Tukey HSD post hoc test, ^{2} Fisher’s exact test, and ^{3} KruskalWallis test, adjusted for multiple comparisons by Bonferroni post hoc test.
 (_{a, b, c}): Each subscript letter denotes the groups whose parameter do not differ significantly from each other after adjustment for multiple comparisons by post hoc test at the level of 0.05
 NS nonsignificant at P value ≥ 0.05; S significant at P value < 0.05; HS highly significant at P value < 0.01