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Table 5 Potential risk factors independently associated with vascular complications in diabetic patients

From: Plasminogen activator inhibitor-1 gene polymorphism as a risk factor for vascular complications in type 2 diabetes mellitus

Variables Univariable analysis Multivariable analysis
OR (95% CI) P valuea Adjusted OR (95% CI) AdjustedP valuea
Age (years) 1.03 (0.99–1.08) 0.147 NS
Sex (male) 1.09 (0.58–2.05) 0.791 NS
Smoking 1.23 (0.66–2.33) 0.515 NS
Hypertension 1.19 (0.53–2.67) 0.673 NS
Dyslipidemia 3.66 (0.42–31.93) 0.240 NS
Duration of DM(years) 1.11 (0.93–1.33) 0.242 NS
PAI-1 genotypes: 0.018 S
Genotype (5G/5G) Ref. (1.00)
Genotype (4G/5G) 3.55 (1.47–8.56) 0.005 HS
Genotype (4G/4G) 2.54 (1.01–6.37) 0.047 S
Dominant: (4G/4G + 4G/5G) 3.09 (1.33–7.17) 0.009 HS
PAI-1 1.06 (1.04–1.08) < 0.001 HS 1.06 (1.03–1.09) < 0.001 HS
TAFI 1.04 (1.03–1.05) < 0.001 HS
d-dimer (mg/dl) 1.58 (1.20-2.07) < 0.001 HS
BMI (kg/m3) 0.97 (0.89-1.06) 0.483 NS
FBS (mg/dl) 1.01 (1.00-1.03) 0.034 S 1.00 (0.99–1.02) 0.871 NS
2Hr PBS (mg/dl) 1.01 (1.00-1.03) 0.007 S
T.C (mg/dl) 1.01 (1.00-1.03) 0.083 NS 1.00 (0.98–1.01) 0.646 NS
Triglycerides (mg/dl) 1.02 (1.01-1.03) 0.006 S 1.01 (1.00–1.03) 0.107 NS
LDL (mg/dl) 1.00 (0.98-1.01) 0.680 NS
HDL (mg/dl) 1.16 (1.09-1.24) < 0.001 HS 1.18 (1.11–1.26) < 0.001 HS
  1. DM diabetes mellitus, OR (95%CI) odd ratio with 95% confidence interval
  2. NS non-significant at P value ≥ 0.05; S significant at P value < 0.05; HS highly significant at P value < 0.01
  3. aWald test