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Table 5 Potential risk factors independently associated with vascular complications in diabetic patients

From: Plasminogen activator inhibitor-1 gene polymorphism as a risk factor for vascular complications in type 2 diabetes mellitus

Variables

Univariable analysis

Multivariable analysis

OR (95% CI)

P valuea

Adjusted OR (95% CI)

AdjustedP valuea

Age (years)

1.03 (0.99–1.08)

0.147 NS

–

–

Sex (male)

1.09 (0.58–2.05)

0.791 NS

–

–

Smoking

1.23 (0.66–2.33)

0.515 NS

–

–

Hypertension

1.19 (0.53–2.67)

0.673 NS

–

–

Dyslipidemia

3.66 (0.42–31.93)

0.240 NS

–

–

Duration of DM(years)

1.11 (0.93–1.33)

0.242 NS

–

–

PAI-1 genotypes:

–

0.018 S

–

–

Genotype (5G/5G)

Ref. (1.00)

–

–

–

Genotype (4G/5G)

3.55 (1.47–8.56)

0.005 HS

–

–

Genotype (4G/4G)

2.54 (1.01–6.37)

0.047 S

–

–

Dominant: (4G/4G + 4G/5G)

3.09 (1.33–7.17)

0.009 HS

–

–

PAI-1

1.06 (1.04–1.08)

< 0.001 HS

1.06 (1.03–1.09)

< 0.001 HS

TAFI

1.04 (1.03–1.05)

< 0.001 HS

–

–

d-dimer (mg/dl)

1.58 (1.20-2.07)

< 0.001 HS

–

–

BMI (kg/m3)

0.97 (0.89-1.06)

0.483 NS

–

–

FBS (mg/dl)

1.01 (1.00-1.03)

0.034 S

1.00 (0.99–1.02)

0.871 NS

2Hr PBS (mg/dl)

1.01 (1.00-1.03)

0.007 S

–

–

T.C (mg/dl)

1.01 (1.00-1.03)

0.083 NS

1.00 (0.98–1.01)

0.646 NS

Triglycerides (mg/dl)

1.02 (1.01-1.03)

0.006 S

1.01 (1.00–1.03)

0.107 NS

LDL (mg/dl)

1.00 (0.98-1.01)

0.680 NS

–

–

HDL (mg/dl)

1.16 (1.09-1.24)

< 0.001 HS

1.18 (1.11–1.26)

< 0.001 HS

  1. DM diabetes mellitus, OR (95%CI) odd ratio with 95% confidence interval
  2. NS non-significant at P value ≥ 0.05; S significant at P value < 0.05; HS highly significant at P value < 0.01
  3. aWald test