The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

Egyptian Journal of Medical Human Genetics

Table 1 Demographic data of young mothers with DS in comparison to control mothers

Variable		DS mothers	Control mothers	OR (95% CI)	P value
Consanguinity	Present	23 (46%)	10 (20%)	3.40 (1.4–8.20)	0.006*
Consanguinity	Absent	27 (54%)	40 (80%)	3.40 (1.4–8.20)	0.006*
Socioeconomic status	High	19 (38%)	35 (70%)	3.80 (1.65–8.74)	0.001*
Socioeconomic status	Low	31 (62%)	15 (30%)	3.80 (1.65–8.74)	0.001*
Residency area	Rural	30 (60%)	18 (36%)	2.66 (1.18–5.98)	0.017*
Residency area	Urban	20 (40%)	32 (64%)	2.66 (1.18–5.98)	0.017*