The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

Egyptian Journal of Medical Human Genetics

Table 3 The frequency of chromatid and chromosome breaks in young mothers with DS children and control mothers

Cytogenetic defect	DS mothers	Control mothers	OR (95% CI)	P value
Chromatid breaks
Frequency	34/50 (68%)	10/50 (20%)	8.50 (3.411–21.17)	< 0.001*
Mean ± SD	3.68 ± 2.54	1.29 ± 0.84
Chromosome breaks
Frequency	18/50 (36%)	6/50 (12%)	3.93 (1.40–11.05)	0.009*
Mean ± SD	2.45 ± 3.32	0.86 ± 0.69