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Table 3 The frequency of chromatid and chromosome breaks in young mothers with DS children and control mothers

From: The demographic data and the high frequency of chromosome/chromatid breaks as biomarkers for genome integrity have a role in predicting the susceptibility to have Down syndrome in a cohort of Egyptian young-aged mothers

Cytogenetic defect DS mothers Control mothers OR (95% CI) P value
Chromatid breaks     
 Frequency 34/50 (68%) 10/50 (20%) 8.50 (3.411–21.17) < 0.001*
 Mean ± SD 3.68 ± 2.54 1.29 ± 0.84   
Chromosome breaks     
 Frequency 18/50 (36%) 6/50 (12%) 3.93 (1.40–11.05) 0.009*
 Mean ± SD 2.45 ± 3.32 0.86 ± 0.69   
  1. *Statistically significant at P ≤ 0.05