Table 3 Association between PIAS3 fold expression and miRNA-18a fold expression and clinicopathological characteristics of studied patients
From: The role of protein inhibitor of activated STAT3 and miRNA-18a expressions in breast cancer
Variables | miRNA-18a Median (Min–Max) | U/H | p value | PIAS3 Median (Min–Max) | U/H | p value |
|---|---|---|---|---|---|---|
Age | ||||||
> 50 | 1.7 (0.1–34.5) | 53.50 | 0.202 | 0.7 (0.0–36.0) | U = 75.0 | 0.936 |
≤ 50 | 0.6 (0.2–3.6) | 0.8 (0.1–12.0) | ||||
Focality | ||||||
Unifocal | 0.7 (0.1–34.5) | 20.50 | 0.807 | 0.5 (0.0–36.0) | U = 13.0 | 0.373 |
Multifocal | 2.1 (0.5–3.6) | 4.1 (0.9–7.3) | ||||
Tumor size | ||||||
< 2 cm | 0.7 (0.1–34.5) | 63.00 | 0.467 | 0.8 (0.0–36.0) | U = 70.0 | 0.727 |
≥ 2 cm | 1.1 (0.3–17.9) | 0.5 (0.1 –13.9) | ||||
Histopathological type | ||||||
IDC | 0.7 (0.1–17.9) | 36.00 | 0.794 | 0.6 (0.1–36.0) | U = 36.0 | 0.794 |
ILC | 3.6 | 0.9 | ||||
Others | 2.0 (0.3–34.5) | 2.5 (0.0–13.9) | ||||
Pathological grade | ||||||
GI | 2.0 (0.3–34.5) | 4.758* | 0.029* | 2.51 (0.0–13.9) | H = 2.397 | 0.302 |
GII | 0.6 (0.1–6.3) | 0.9 (0.1–36.0) | ||||
GIII | 3.1 (0.4–17.9) | 0.3 (0.1–0.9) | ||||
Lymphovascular invasion | ||||||
Negative | 3.8 (0.3–34.5) | 21.500 | 0.353 | 0.15 (0.03–13.93) | U = 23.0 | 0.446 |
Positive | 0.7 (0.1–17.9) | 0.84 (0.13–36.0) | ||||
LN metastasis | ||||||
No | 0.6 (0.2–34.5) | 74.5 | 0.852 | 0.41 (0.03–36.0) | U = 67.50 | 0.574 |
Yes | 1.1 (0.1–6.3) | 0.90 (0.14–33.82) | ||||
TNM stage | ||||||
0 | 34.5 | 1.744 | 0.418 | 0 | H = 3.008 | 0.390 |
IA | 0.5 (0.2–3.8) | 0.9 (0.1–36.0) | ||||
IIA + IIB | 1.5 (0.2–17.9) | 0.8 (0.1–12.0) | ||||
III | 0.7 (0.1–3.6) | 0.9 (0.1–33.8) | ||||
ER | ||||||
Positive | 0.7 (0.1–34.5) | 36.00 | 0.371 | 0.8 (0.0–36.0) | U = 43.0 | 0.668 |
Negative | 1.9 (0.4–5.5) | 0.5 (0.1–10.9) | ||||
PR | ||||||
Positive | 0.7 (0.1–34.5) | 36.00 | 0.371 | 0.8 (0.0–36.0) | U = 43.0 | 0.668 |
Negative | 1.9 (0.4–5.5) | 0.5 (0.1–10.9) | ||||
HER2 | ||||||
Positive | 0.9 (0.1–34.5) | 49.50 | 0.974 | 0.6 (0.0–36.0) | U = 48.0 | 0.921 |
Negative | 0.7 (0.2–17.9) | 1.3 (0.1–7.3) | ||||
Molecular type | ||||||
Luminal A | 0.7 (0.2–17.9) | 0.985 | 0.611 | 1.3 (0.1–7.3) | H = 0.296 | 0.863 |
Luminal B | 0.7 (0.1–34.5) | 0.8 (0.0–36.0) | ||||
HER2 enriched | 1.9 (0.4–5.5) | 0.5 (0.1–10.9) | ||||