Adiponectin and human eating behaviour: a Mendelian randomization study

Egyptian Journal of Medical Human Genetics

Table 3 Estimates of standardized mean difference, standard error, P values (and 95% confidence interval [CI]) of three eating behaviour factors per 1 U increase in genetically instrumented log adiponectin levels from various Mendelian randomization methods

MR method	EB factor restraint				EB factor disinhibition				EB factor hunger
MR method	β	SE	95% CI	P	β	SE	95% CI	P	β	SE	95% CI	P
IVW	0.17	1.03	− 1.85, 2.18	0.87	3.05	1.00	1.10, 5.00	0.002	1.63	1.22	− 0.75, 4.01	0.18
Weighted median	0.98	1.15	− 1.28, 3.24	0.40	2.66	1.11	0.48, 4.84	0.02	1.23	1.09	− 0.90, 3.36	0.26
Weighted modal	1.07	1.12	− 1.12, 3.26	0.34	2.63	1.07	0.54, 4.73	0.01	1.12	1.03	− 0.90, 3.14	0.28
MR Egger	3.85	2.23	− 0.52, 8.21	0.08	− 0.32	2.23	− 4.69, 4.04	0.88	− 1.53	2.74	− 6.89, 3.83	0.58
Constant^†	− 0.25	0.14	− 0.53, 0.02	0.07	0.23	0.14	− 0.04, 0.51	0.10	0.22	0.17	− 0.12, 0.55	0.20

CI confidence interval, U unit, EB eating behaviour, IVW inverse-variance weighted regression method, β beta coefficient, SE standard error
^†MR-Egger intercept