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Table 2 Methylation percentage of p14/ARF gene among the studied subgroups of breast cancer risk factors

From: Determinants of p14/ARF methylation in healthy females: association with reproductive and non-reproductive risk factors of breast cancer

Parameter (n)

Groups (n)

Means ± SD

p value

Age (120)

 

<  40 years (60)

30.31 ± 1.73

0.029

 

≥ 40 years (60)

31.8 ± 3.1

Family history (120)

 

No (60)

31.12 ± 3.17

0.671

 

Yes (60)

30.83 ± 1.89

Age at menarche (120)

 

< 14 years (64)

31.02 ± 2.8

0.820

 

≥ 14 years (56)

30.8 ± 2.3

Menopausal state (120)

 

Premenopausal (88

30.75 ± 2.6

0.276

 

Postmenopausal (32)

31.6 ± 2.7

Number of children (100)

 

1–2 children (12)

31.28±

0.838

 

> 2 children (88)

31.03±

Breastfeeding duration (100)

 

6–18 months (50)

31.45 ± 2.4

0.183

 

19–24 months (50)

30.48 ± 2.5

BMI (116)

 

25–29 kg/m2 (52)

31.4 ± 3.2

0. 275

 

> 30 kg/m2 (64)

30.7 ± 2

Parity (120)

 

Nulliparous (20)

30.5 ± 1.5

0.379

 

Multiparous (100)

31.2 ± 2.7

Age at full-term pregnancy (100)

 

< 25 years (14)

30.4 ± 1.8

0.368

 

> 25 years (86)

31.14 ± 2.8

  1. The continuous data were expressed as means ± SD. Independent sample t test showed the difference of p14/ARF methylation percentage between the subgroups. BMI: body mass index. P value is significant if  less than 0.05