Clinicopathological features of Egyptian colorectal cancer patients regarding somatic genetic mutations especially in KRAS gene and microsatellite instability status: a pilot study

Egyptian Journal of Medical Human Genetics

Table 3 Correlation of patients’ clinicopathological features with KRAS mutational status and MSI status

CRC patients’ characteristics	KRAS wild (N = 13/19)	KRAS mutant (N = 6/19)	p value	MSI-H (N = 11/19)	MSI-L/MSS (N = 8/19)	p value
Gender
Males	6	1	0.22	2	5	0.048*
Females	7	5		9	3	0.048*
Age (years)	33 ± 14.37	56.5 ± 12.57	0.003*	43.09 ± 19.28	36.75 ± 15.26	0.45
Tumor location
Proximal colon	8	2		6	4
Distal colon	2	4	0.18	2	4	0.06
Rectum	3	0		3	0	0.06
Tumor site
Left	5	4	0.25	5	4	0.85
Right	8	2		6	4	0.85
Size of tumor (cm)
< 5	9	5	0.52	8	6	0.91
≥ 5	4	1		3	2	0.91
Tumor stage
II	5	3		5	3	0.59
III	7	3	0.74	5	5
IV	1	0		1	0
No. of nodes
N0 (0)	7	3		6	4	0.85
N1 (1–3)	5	3		4	4
N2 (> 3)	1	0		1	0
			0.88
Depth of invasion
T3	12	6	0.49	10	8	0.38
T4	1	0		1	0	0.38
Distant metastasis
Yes	1	0	0.49	1	0	0.38
No	12	6		10	8	0.38
MSI-H (N = 11/19)	8	3		–	–	–
MSI-L/MSS (N = 8/19)	5	3	0.63