Fig. 1From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stabilityTen different computational tools utilized to predict the most deleterious effect of amino acid substitutions on leptin structure, function, and stability. These tools cumulatively showed that the most deleterious substitutions are D76V, C117S, and L161RBack to article page