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Fig. 3 | Egyptian Journal of Medical Human Genetics

Fig. 3

From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stability

Fig. 3

Stereochemical comparison among three common 3D structure modeling servers in terms of generating the best tertiary structure of leptin. a) RaptorX generated leptin. b) PhyRe2 generated leptin. c) I-TASSER generated leptin. All parameters revealed from RaptorX built structures showed accepted limit values and more qualified parameters compared with PhyRe2 and I-TASSER built structures, respectively. The 3D structure is validated by side chain parameters of PROCHECK tool

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