Skip to main content
Egyptian Journal of Medical Human Genetics
Fig. 4 | Egyptian Journal of Medical Human Genetics

Fig. 4

From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stability

Fig. 4

Spatial superimposition of the native leptin and the most deleterious mutants predicted in this study. (a) 3D model of wild type leptin protein. (b) Superimposed structures of wild type leptin and its mutant protein having a mutation from Asp (D) to Val (V) at 76th position, c) from Cys (C) to Ser (S) at 117th position, d) from Leu (L) to Lys (R) at 161th position. Superimposition is made by TM-align server and superimposed 3D structures are viewed by PyMol software

Back to article page