Fig. 6From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stabilityThe most deleterious amino acid substitutions predicted in leptin 3D structures. a) The wild type D and the mutant V residues at 78th position (D78V). b) The wild type C and the mutant S residues at 117th position (C117S). c) The wild type L and the mutant R residues at 161th position (L161R). The protein is shown in ribbon-presentation and colored grey. The wild type amino acid residues affected by mutations are shown in green, while their mutant counterparts are shown in red. Structures are generated by HOPE serverBack to article page