Table 3 MutPred prediction for the most deleterious missense variants observed in LEP gene
| Variant | MutPred2 score | Remarks | Affected PROSITE and ELM Motifs |
|---|---|---|---|
| D76V | 0.436 | – | – |
| C117S | 0.735 | - | ELME000063 |
| Molecular mechanisms with P values ≤ 0.05 | Probability | P value | |
| Altered metal binding | 0.39 | 6.9e–03 | |
| L161R | 0.720 | – | ELME000106, ELME000136, ELME000159 |
| Molecular mechanisms with P values ≤ 0.05 | Probability | P value | |
| Gain of intrinsic disorder | 0.36 | 0.02 | |
| Altered stability | 0.21 | 0.01 | |
| Altered transmembrane protein | 0.14 | 0.02 |