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Table 3 MutPred prediction for the most deleterious missense variants observed in LEP gene

From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stability

VariantMutPred2 scoreRemarksAffected PROSITE and ELM Motifs
D76V0.436
C117S0.735-ELME000063
 Molecular mechanisms with P values ≤ 0.05ProbabilityP value
 Altered metal binding0.396.9e–03
L161R0.720ELME000106, ELME000136, ELME000159
 Molecular mechanisms with P values ≤ 0.05ProbabilityP value
 Gain of intrinsic disorder0.360.02
 Altered stability0.210.01
 Altered transmembrane protein0.140.02