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Table 4 TM-align predictions for the most three deleterious nsSNPs in leptin

From: D76V, L161R, and C117S are the most pathogenic amino acid substitutions with several dangerous consequences on leptin structure, function, and stability

NsSNP IDAmino acid changeAligned lengthTM-scoreRMSD (Å)
rs1332916395D76V1530.829420.948
rs1051206328C117S1660.935780.940
rs771956117L161R1520.837380.967