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Table 1 General characteristics of the studied lung cancer patients and control subjects

From: Gene-environment and gene-gene interactions between CHRNA3 rs1051730, XRCC1 rs25487, and ERCC1 rs735482 variants highly elevate the risk of lung cancer

Variable

Lung cancer (N = 86)

Controls (N = 64)

p value

OR (95% CI)/P

Age (years)

Mean ± SD (Range)

54.2 ± 10.5 (27–75)

50.2 ± 8.5 (37–70)

0.08a

 

Age group

< 45 year n (%)

14 (16.3)

18 (28.1)

0.2b

2.0 (0.6–6.1)/0.2

≥ 45 year n (%)

72 (83.7)

46 (71.9)

 

Gender

Male n (%)

70 (81.4)

26 (40.6)

0.001*b

6.4 (2.2–18.1)/< 0.001*

Female n (%)

16 (19.6)

38 (59.4)

Histological type n (%)

SCLC

12 (14)

   

NSCLC

74 (86)

   

 Adenocarcinoma

52 (70.3)

   

 Squamous cell carcinoma

6 (8.1)

   

 Othersd

16 (21.6)

   

Smoking (Yes/No)

   

Non-smokers n (%)

26(30.3)

50(78.2)

<0.0001*b

8.2(2.8-23.7)/< 0.0001*

Smoker n (%)

60(69.7)

14(21.8)

<0.0001*b

 

Pack-year (mean)

44.9

28.7

0.001*c

1.0 (0.9-1.1)/0.03*

  1. NSCLC non-small cell lung cancer, SCLC small cell lung cancer carcinoma, anaplastic
  2. *Significant P
  3. aP value for independent t test
  4. bP value for χ2 test
  5. cP value for Mann–Whitney U test
  6. dLarge cell carcinoma, undifferentiated, spindle, mucinous, Broncho alveolar carcinoma, carcinoid, sarcomatoid