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Table 2 Genotypes and alleles frequencies of the studied SNP in lung cancer patients and control subjects

From: Gene-environment and gene-gene interactions between CHRNA3 rs1051730, XRCC1 rs25487, and ERCC1 rs735482 variants highly elevate the risk of lung cancer

 

Lung cancer patients (n = 86)

f %

Controls (n = 64)

f %

rs1051730

A/A

14 (16.2)

8 (12.5)

A/G

46 (53.5)

34 (53.1)

G/G

26 (30.3)

22 (34.4)

P-value

0.8

Allele A

74 (42.0)

50 (39.1)

Allele G

98 (58.0)

78 (60.9)

HWE

p value = 0.36

p value = 0.43

rs25487

A/A

56 (65.1)

48 (75.0)

A/C

26 (30.2)

16 (25.0)

C/C

4 (4.7)

0

p value

0.3

Allele A

138 (80.2)

112 (87.5)

Allele C

34 (19.8)

16 (12.5)

HWE

p value = 0.09

p value = 0.6

rs735482

A/A

38 (44.2)

38 (59.4)

A/G

40 (46.5)

20 (31.2)

G/G

8 (9.3)

6 (9.4)

p value

0.3

Allele A

116 (67.4)

96 (75.0)

Allele G

56 (32.6)

32 (25.0)

HWE

p value = 0.1

p value = 0.8

  1. HWE Hardy–Weinberg equilibrium