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Egyptian Journal of Medical Human Genetics

Table 6 Gene-gene interaction in lung cancer patients

From: Gene-environment and gene-gene interactions between CHRNA3 rs1051730, XRCC1 rs25487, and ERCC1 rs735482 variants highly elevate the risk of lung cancer

Haplotype

p value

OR (95% CI)

rs1051730 with rs735482

A A

Reference

 

G G

<0.0001*

20.8 (10.5–41.3)

A G

<0.0001*

9.9(4.8–20.2)

G A

<0.0001*

2.7 (1.5–4.8)

rs1051730 with rs25487

AA

Reference

 

G A

0.5

1.1 (0.7–1.9)

A C

0.1

2.1 (0.8–5.3)

G C

0.2

1.6 (0.7–3.8)

rs25487 with rs735482

A A

Reference

 

A G

0.1

1.5 (0.8–2.7)

C A

0.09

2.0 (0.8–4.7)

C G

0.2

1.8 (1.8–4.7)

  1. The underline indicates the variant allele of the specific gene
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