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Table 1 Correlation analysis of YAP1 promoter methylation with different variables

From: Aberrant methylation of yes-associated protein (YAP1) as a potential biomarker in breast cancer

Variable

Total

n (%)

Unmethylated

Nā€‰=ā€‰16 (%)

Methylated

Nā€‰=ā€‰34 (%)

Test of Significance

p value

Age (years)

ā€ƒā‰¤ā€‰50

31 (62)

12 (38.7)

19 (61.3)

Ļ‡2ā€‰=ā€‰1.688

0.194

ā€ƒĖƒĀ 50

19 (38)

4 (21.1)

15 (78.9)

BMI (kg/m2)

ā€ƒā‰¤ā€‰25

14 (28)

6 (42.9)

8 (57.1)

Ļ‡2ā€‰=ā€‰1.053

FEpā€‰=ā€‰0.330

ā€ƒĖƒĀ 25

36 (72)

10 (27.8)

26 (72.2)

Menopausal state

ā€ƒPremenopausal

17 (34)

4 (23.5)

13 (76.5)

Ļ‡2ā€‰=ā€‰0.849

0.357

ā€ƒPostmenopausal

33 (66)

12 (36.4)

21 (63.6)

Histopathological type

ā€ƒDuctal

34 (68)

12 (35.3)

22 (64.7)

Ļ‡2ā€‰=ā€‰0.534

MCpā€‰=ā€‰0.884

ā€ƒLobular

12 (24)

3 (25)

9 (75)

ā€ƒOthers

4 (8)

1 (25)

3 (75)

Tumor stage

ā€ƒI

Ā Ā Ā 

Ļ‡2ā€‰=ā€‰34.124*

<ā€‰0.001*

ā€ƒII

18 (36)

15 (83.3)

3 (16.7)

ā€ƒIII

22 (44)

1 (4.5)

21 (95.5)

ā€ƒIV

10 (20)

0 (0)

10 (100)

Tumor size

ā€ƒā‰¤ā€‰2ā€‰cm

3 (6)

2 (66.7)

1 (33.3)

Ļ‡2ā€‰=ā€‰1.763

FEpā€‰=ā€‰0.237

ā€ƒ>ā€‰2ā€‰cm

47 (94)

14 (29.8)

33 (70.2)

Axillary lymph node involvement

ā€ƒYes

47 (94)

14 (29.8)

33 (70.2)

Ļ‡2ā€‰=ā€‰1.763

FEpā€‰=ā€‰0.237

ā€ƒNo

3 (6)

2 (66.7)

1 (33.3)

ā€ƒNo

40 (80)

16 (40)

24 (60)

Estrogen receptor status (ER)

ā€ƒPositive

42 (84)

13 (31)

29 (69)

Ļ‡2ā€‰=ā€‰0.132

FEpā€‰=ā€‰0.699

ā€ƒNegative

8 (16)

3 (37.5)

5 (62.5)

Progesterone receptor status (PR)

ā€ƒPositive

43 (86)

14 (32.6)

29 (67.4)

Ļ‡2ā€‰=ā€‰0.044

FEpā€‰=ā€‰1.000

ā€ƒNegative

7 (14)

2 (28.6)

5 (71.4)

HER2 expression status

ā€ƒOverexpression

16 (32)

2 (12.5)

14 (87.5)

Ļ‡2ā€‰=ā€‰4.112*

0.043*

ā€ƒNon-overexpression

34 (68)

14 (41.2)

20 (58.5)

CA15ā€“3 (U/ml)

ā€ƒMeanā€‰Ā±ā€‰SD

37.49ā€‰Ā±ā€‰28.17

28.78ā€‰Ā±ā€‰12.94

41.59ā€‰Ā±ā€‰32.37

tā€‰=ā€‰1.520

0.135

ā€ƒMedian (minā€“max)

34 (11ā€“190)

Ā Ā 
  1. Ļ‡2 chi-square test, FE Fisherā€™s exact, MC Monte Carlo, t Studentā€™s t test, p p value for comparing between the two groups
  2. *Statistically significant at pā€‰ā‰¤ā€‰0.05