Association between fibrinogen receptor (Glycoprotein IIb) polymorphism and the risk of venous thromboembolism: a systematic review

Egyptian Journal of Medical Human Genetics

Table 1 Extracted data from included studies investigating the correlation between PLA2 polymorphism and VTE

Author	Country	Patients number	Median age	OR	95% CI	Type of disease	Frequency of PLA2 polymorphism (%)	p value
Ridker et al 1997	USA	121	61	1.07	0.7–1.6	VTE	28.1	0.5
Ivanov et al 2008	Bulgaria	51	48.7/45.47	3.27	1.36–7.93	PE	35.3	0.003
Atzeni et al 2011	Italy	36	34	2.2	1.1–4.5	Behcet's diseases with DVT	41.7	0.04
Pourgheysari et al 2012	Iran	72	52.12	3.4	1.8–6.44	VTE	27.8	< 0.001
Karimi et al 2015	Iran	23	NR	1.33	0.37–4.71	PE/DVT	13	NS
		37		1.37	0.5–3.82	PE	13.5	NS
		35		6.65	3.09-14.30	DVT	42.9	< 0.001

NR data not reported, NS not significant, N number, OR odds ratio, CI confidence interval, VTE venous thromboembolism, PE pulmonary embolism, DVT deep vein thrombosis