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Table 1 Demographic data of the three studied groups

From: TNF-α -308 G>A and IL10 -1082A>G polymorphisms as potential risk factors for lymphoproliferative disorders in autoimmune rheumatic diseases

 

Group I

(n = 25)

Group II

(n = 25)

Group III

(n = 20)

Test of Sig.

p

Age (yrs)

 Median (Min. – Max.)

40 (30-62)

43.5(26-58)

50 (41-55)

F =3.008

0.056

 Mean ± SD.

44± 10.5

43.3± 9.7

49.8± 5

Sex

 Male

2 (8%)

8 (32%)

9 (45%)

χ2=8.16*

0.017*

 Female

23 (92%)

17 (68%)

11 (55%)

ARD

 RA

n=15

-

n= 9

-

-

 SLE

n= 10

-

n=11

-

-

LPD subtypes

 HL

-

n= 7

--

-

-

 B-CLL

-

n= 10

n= 6

-

-

 NHL

-

n= 8

n=12

-

-

  DLBCL

-

6

7

-

-

  MCL

-

-

1

-

-

  FL

-

1

1

-

-

  T-cs lymphoma

-

1

3

-

-

 Castleman’s disease

-

-

n= 2

-

-

Duration of ARD (yrs)

 Median (Min. – Max.)

9 (6-18)

10 (2-13)

U =202.0

0.440

 Mean ± SD.

18 ± 10.2

13 ± 8.9

Duration of LPD (yrs)

 Median (Min. – Max.)

7.5 (6-12)

2 (1-10)

U =40.0*

<0.001*

 Mean ± SD.

7.9 ± 1.8

3.3 ± 2.8

Activity score

 DAS28 (for RA)

3-5

-

5.1-7

  

 BILAG-2004 (for SLE)

8-12

 

>12

  

Joint affected

 Small

18(72%)

5(20%)

13(65%)

χ2 =15.60

<0.001*

 Small and Large

7(28%)

20(80%)

7 (35%)

LN enlargement

1(4%)

17(68%)

14 (70%)

χ2 =27.29

<0.001*

HSM

1(4%)

11 (44%)

7(35%)

χ2 =11.00

0.004*

Pancytopenia

2(8%)

12(48%)

9 (45%)

χ2 =10.94

0.004*

B-symptomsa

2(8%)

15 (60%)

14(70%)

χ2 =21.20

<0.001*

  1. χ2 Chi square test, F ANOVA test, U Mann Whitney test, yrs years, ARD autoimmune rheumatic disease, RA Rheumatoid arthritis, SLE Systemic lupus erythematosus, LPD lymphoproliferative disorders, HL Hodgkin’s lymphoma, B-CLL B- Chronic lymphocytic leukemia, NHL Non-Hodgkin’s lymphoma, DLBCL Diffuse large B-cell lymphoma, MCL Mantle cell lymphoma, FL follicular lymphoma, DAS28 disease activity score 28, BILAG-2004 index Index system for assessment of SLE activity, LN lymph node, HSM hepatosplenomegaly
  2. *Statistically significant at p ≤ 0.05
  3. aB-symptoms includes sweating, weight loss and fever