Table 3 Distribution frequency of the cytokine genes polymorphisms alleles
Cytokine polymorphism alleles | Group I (n = 50) | Group II (n = 50) | Group III (n = 40) | χ2 | p | OR# (95%CI) |
|---|---|---|---|---|---|---|
No. (%) | No. (%) | No. (%) | ||||
TNF-α promoter | ||||||
-308G | 27 (54) | 11 (22) | 12 (30) | 11.95 | 0.003* | 0.37 (0.15-0.88) |
-308A | 23 (46) | 39 (88) | 28 (70) | 2.74 (1.14-6.57) | ||
p1=0.022* p2= 0.001* p3=0.387 | ||||||
TGF-β1 codon gene | ||||||
Codon 10 | ||||||
10T | 27 (54) | 29 (58) | 26 (65) | 1.12 | 0.572 | 1.58 (0.67 – 3.72) |
10C | 23 (46) | 21 (42) | 14 (35) | 0.63 (0.27 – 1.49) | ||
Codon 25 | ||||||
25G | 45 (90) | 43 (86) | 36 (90) | 0.508 | 0.776 | 1.0 (0.25-3.99) |
25C | 5 (10) | 7 (14) | 4 (10) | 1.0 (0.25–3.99) | ||
IL-10 promoter | ||||||
-1082 | ||||||
A | 24 (48) | 39 (88) | 30 (75) | 11.93 | 0.003* | 3.25 (1.31-8.04) |
G | 26 (52) | 11 (22) | 10 (25) | 0.31 (0.12 – 0.76) | ||
p1=0.009* p2=0.002* p3=0.74 | ||||||
-819 | ||||||
T | 11 (22) | 21 (42) | 17 (42.5) | 5.78 | 0.06 | 2.6 (1.05 – 6.56) |
C | 39 (88) | 29 (58) | 23 (57.5) | 0.38 (0.15 – 0.95) | ||
-592 | ||||||
A | 17 (34) | 21 (42) | 18 (45) | 1.25 | 0.53 | 1.59 (0.67 – 3.73) |
C | 33 (66) | 29 (58) | 22 (55) | 0.63 (0.27 – 1.48) | ||
IL-6 Promoter | ||||||
-174G | 31 (62) | 37 (74) | 20 (50.0) | 5.507 | 0.064 | 0.61 (0.26 – 1.42) |
-174C | 19 (38) | 13 (25) | 20 (50.0) | 1.63 (0.7 – 3.79) | ||
IFN-γ gene: | ||||||
+874T | 25 (50) | 27 (54) | 22 (55) | 0.264 | 0.876 | 1.22 (0.53 – 2.81) |
+874A | 25 (50) | 23 (46) | 18 (45) | 0.82 (0.35 – 1.88) | ||