TNF-α -308 G>A and IL10 -1082A>G polymorphisms as potential risk factors for lymphoproliferative disorders in autoimmune rheumatic diseases

Egyptian Journal of Medical Human Genetics

Table 4 Distribution frequency of cytokine genes polymorphisms alleles among RA/SLE patients in group I and III

	RA				χ² (p)	OR	SLE				χ² (p)	OR
	Group I (n = 30)		Group III (n = 18)				Group I (n = 20)		Group III (n = 22)
	No.	%	No.	%			No.	%	No	%
TNF-α promoter
-308G	15	50.0	3	16.7	5.3 (0.02)*	0.2 (0.05 -0.84)	12	60.0	9	40.9	1.53 (0.22)	0.5 (0.13-1.58)
-308A	15	50.0	15	83.3	5.3 (0.02)*	5.0 (1.19-20.9)	8	40.0	13	59.1	1.53 (0.22)	2.17(0.63-7.44)
TGF-β1 codon gene
10T	11	36.7	11	61.1	2.69 (0.1)	2.71(0.81-9.05)	16	80.0	15	68.1	0.76 (0.38)	0.54 (0.13 - 2.2)
10C	19	63.3	7	38.9	2.69 (0.1)	0.37 (0.11-1.23)	4	20.0	7	31.8	0.76 (0.38)	1.87(0.45 – 7.7)
25G	25	83.3	18	100.0	3.35 (0.067)	7.2 (0.403-140.3)	20	100.0	19	86.4	2.94(0.86)	0.16(0.01- 3.4)
25C	5	16.7	0	0.0	3.35 (0.067)	0.14 (0.01-2.7)	0	0.0	3	13.6	2.94(0.86)	6.3(0.3-134.6)
IL-10 promoter
-1082 A	10	36.7	13	72.2	6.82 (0.009)*	5.2(1.44-18.7)	14	70.0	17	77.3	0.3(0.6)	1.5 (0.37-5.8)
-1082 G	20	63.3	5	27.8	6.82 (0.009)*	0.2 (0.05-0.7)	6	30.0	5	22.7	0.3(0.6)	0.7 (0.17-2.7)
-819T	7	23.3	9	50.0	3.6 (0.06)	3.3 (0.93-11.5)	4	20.0	9	40.9	2.14 (0.143)	2.7 (0.69-11.1)
-819C	23	76.7	9	50.0	3.6 (0.06)	0.3 (0.09-1.07)	16	80.0	13	59.1	2.14 (0.143)	0.36 (0.09-1.44)
-592A	9	30	9	50.0	1.92 (0.17)	2.3 (0.70-7.8)	8	40.0	9	40.9	0.004(0.95)	1.04 (0.3-3.57)
-592C	21	70	9	50.0	1.92 (0.17)	0.43 (0.13-1.44)	12	60.0	13	59.1	0.004(0.95)	0.96 (0.28-3.31)
IL-6 promoter
-174G	19	63.3	11	61.1	0.024(0.88)	0.91 (0.27 -3.03)	12	60.0	9	40.9	1.53 (0.216)	0.46 (0.13-1.58)
-174C	11	36.7	7	38.9	0.024(0.88)	1.1 (0.33 -3.66)	8	40.0	13	59.1	1.53 (0.216)	2.2 (0.63-7.44)
IFN-γ gene:
+874T	17	56.7	9	50.0	0.20 (0.65)	0.77 (0.23-2.5)	8	40.0	13	40.9	1.53 (0.216)	2.2 (0.63-7.44)
+874A	13	43.3	9	50.0	0.20 (0.65)	1.31 (0.40-4.22)	12	60.0	9	59.1	1.53 (0.216)	0.46 (0.13-1.58)

χ² Chi square test, OR Odds ratio, p p value for comparison between the two studied groups, RA Rheumatoid arthritis, SLE Systemic lupus erythematosus, TNF-α tumor necrosis factor- alpha, TGF-β1 transforming growth factor-β, IL-10 interleukin-10, IL-6 interleukin-6, IFN-γ interferon-gamma
^*Statistically significant at p ≤ 0.05