Cytokine polymorphism genotype | Group I (n = 25) | Group III (n = 20) | χ2 | p | OR (95%CI) |
---|---|---|---|---|---|
No. (%) | No. (%) | ||||
TNF-α promoter | |||||
-308 GG | 10 (40) | 2 (10) | 5.13 | 0.08 | 0.17 (0.03 - 0.88) |
-308AA | 8 (32) | 10 (50) | 2.1 (0.63 - 7.16) | ||
-308GA | 7 (28) | 8 (40) | 1.7 (0.5 – 5.98) | ||
-308GG | 10 (40) | 2 (10) | 5.11 | 0.02* | 0.17(0.032-0.88) |
-308 AA+GA | 15 (60) | 18 (90) | 6.0 (1.13-31.7) | ||
-308 AA | 8 (32) | 10 (50) | 1.5 | 0.22 | 2.13(0.63-7.16) |
-308GA+GG | 17(68) | 10 (50) | 0.47 (0.14-1.58) | ||
-308 GA | 7 (28) | 8 (40) | 0.72 | 0.40 | 1.71 (0.49-5.98) |
-308AA+GG | 18 (72) | 12 (60) | 0.58 (0.17-2.04) | ||
IL-10 promoter | |||||
-1082 AA | 7 (28) | 12 (60) | 5.42 | 0.07 | 3.86 (1.11 – 13.46) |
-1082 GG | 8 (32) | 2 (10) | 0.24 (0.04 – 1.27) | ||
-1082 GA | 10 (40) | 6 (30) | 0.64 (0.18 – 2.24) | ||
-1082AA | 7 (28) | 12 (60) | 4.66 | 0.03* | 3.9 (1.1-13.46) |
-1082GG+GA | 18 (72) | 8 (40) | 0.26 (0.07-0.90) | ||
-1082GG | 8 (32) | 2 (10) | 3.114 | 0.08 | 0.24 (0.04-1.27) |
-1082GA+AA | 17 (68) | 18 (70) | 4.2 (0.78-22.85) | ||
-1082GA | 10 (36) | 6 (30) | 0.48 | 0.49 | 0.64 (0.18-2.2) |
-1082 AA+GG | 15 (64) | 14 (70) | 1.56 (0.45-5.41) | ||
IL10 promoter Haplotype | (n = 50) | (n = 40) | |||
ATA | 8 (16) | 14(35) | 4.34 | 0.04* | 2.8 (1.04-7.66) |
ACC | 16 (32) | 10(25) | 0.53 | 0.47 | 0.71 (0.28-1.80) |
GCC | 18 (36) | 8(16) | 2.77 | 0.09 | 0.44 (0.17 – 1.17) |