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Table 5 Distribution frequency of TNF -308G>A, IL-10-1082A>G genotypes and IL-10 -1082A>G, -819 T>C and -592 G>C haplotypes in ARD (group I), and ARD+LPD (group III) patients

From: TNF-α -308 G>A and IL10 -1082A>G polymorphisms as potential risk factors for lymphoproliferative disorders in autoimmune rheumatic diseases

Cytokine polymorphism genotype

Group I

(n = 25)

Group III

(n = 20)

χ2

p

OR (95%CI)

No. (%)

No. (%)

TNF-α promoter

 -308 GG

10 (40)

2 (10)

5.13

0.08

0.17 (0.03 - 0.88)

  -308AA

8 (32)

10 (50)

2.1 (0.63 - 7.16)

 -308GA

7 (28)

8 (40)

1.7 (0.5 – 5.98)

 -308GG

10 (40)

2 (10)

5.11

0.02*

0.17(0.032-0.88)

 -308 AA+GA

15 (60)

18 (90)

6.0 (1.13-31.7)

 -308 AA

8 (32)

10 (50)

1.5

0.22

2.13(0.63-7.16)

 -308GA+GG

17(68)

10 (50)

0.47 (0.14-1.58)

 -308 GA

7 (28)

8 (40)

0.72

0.40

1.71 (0.49-5.98)

 -308AA+GG

18 (72)

12 (60)

0.58 (0.17-2.04)

IL-10 promoter

 -1082 AA

7 (28)

12 (60)

5.42

0.07

3.86 (1.11 – 13.46)

 -1082 GG

8 (32)

2 (10)

0.24 (0.04 – 1.27)

 -1082 GA

10 (40)

6 (30)

0.64 (0.18 – 2.24)

 -1082AA

7 (28)

12 (60)

4.66

0.03*

3.9 (1.1-13.46)

 -1082GG+GA

18 (72)

8 (40)

0.26 (0.07-0.90)

 -1082GG

8 (32)

2 (10)

3.114

0.08

0.24 (0.04-1.27)

 -1082GA+AA

17 (68)

18 (70)

4.2 (0.78-22.85)

 -1082GA

10 (36)

6 (30)

0.48

0.49

0.64 (0.18-2.2)

 -1082 AA+GG

15 (64)

14 (70)

1.56 (0.45-5.41)

IL10 promoter Haplotype

(n = 50)

(n = 40)

   

 ATA

8 (16)

14(35)

4.34

0.04*

2.8 (1.04-7.66)

 ACC

16 (32)

10(25)

0.53

0.47

0.71 (0.28-1.80)

 GCC

18 (36)

8(16)

2.77

0.09

0.44 (0.17 – 1.17)

  1. χ2 Chi square test, TNF-α tumor necrosis factor- alpha, TGF-β1 transforming growth factor-β, IL-10 interleukin-10, IL-6 interleukin-6, IFN-γ interferon-gamma
  2. p: p value for comparing between the studied groups
  3. OR: Odds ratio for Group I and Group III
  4. 95%CI= 95% confidence interval
  5. *Statistically significant at p ≤ 0.05