Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

Egyptian Journal of Medical Human Genetics

Table 1 Baseline characteristics of studies concerning CaSR R990G gene polymorphism in patients with urolithiasis included in the meta-analysis

Author and year	Case				Control				Ethnicity	Type of stone	Genotyping	X² HWE	NOS [S/C/E]
Author and year	RR	RG	GG	N	RR	RG	GG	N	Ethnicity	Type of stone	Genotyping	X² HWE	NOS [S/C/E]
Ding et al. 2017 [26]	109	348	158	615	76	172	67	315	Asian	Calcium oxalate	PCR	2.72	6[3/1/2]
Hamilton et al. 2009 [30]	51	5	0	56	180	11	0	191	Caucasian	Calcium oxalate	PCR-RFLP	0.17	7[3/2/2]
Han et al. 2013 [31]	20	40	10	70	24	53	17	94	Asian	Calcium oxalate	PCR	1.69	6[3/1/2]
Li et al. 2018 [32]	191	301	132	624	152	217	101	470	Asian	Calcium oxalate	PCR	2.02	8[4/2/2]
Peretokina et al. 2015 [33]	84	23	3	110	60	15	2	77	Caucasian	Calcium oxalate and phosphate	PCR	0.76	6[3/1/2]
Shakhssalim et al. 2010 [27]	87	10	2	99	105	2	0	107	Asian	Calcium oxalate	PCR	0.01	7[4/1/2]
Vezzoli et al. 2007 [28]	105	17	2	124	115	4	0	119	Caucasian	Calcium oxalate	PCR	0.03	6[3/1/2]
Vezzoli et al. 2014 [29]	133	22	0	155	136	5	0	141	Caucasian	Calcium oxalate	PCR	0.05	6[3/1/2]

CaSR calcium-sensing receptor, PCR polymerase chain reaction, PCR-RFLP PCR–restriction fragment length polymorphism, HWE Hardy-Weinberg equilibrium, NOS Newcastle-Ottawa Scale, S selection, C comparability, E exposure