Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

Egyptian Journal of Medical Human Genetics

Table 4 Summay of the association between R990G gene polymorphism and the risk of urolithiasis

Allele and genotype	NS	Model	Value		Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Allele and genotype	NS	Model	Case (%)	Control (%)	Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Overall analysis
R vs. G	8	Random	62.76	71.83	62.76	28.17	0.69	0.51–0.95	0.0010	0.3230	0.0240
G vs. R	8	Random	37.24	28.17	37.24	71.83	1.44	1.05–1.98	0.0010	0.3230	0.0240
RR vs. RG + GG	8	Random	42.09	56.01	42.09	43.99	0.60	0.41–0.89	0.0040	0.4150	0.0120
RG vs. RR + GG	8	Random	41.34	31.64	41.34	68.36	1.48	1.05–2.09	0.0120	0.3360	0.0260
GG vs. RR + RG	8	Fixed	16.57	12.35	16.57	87.65	1.09	0.89–1.35	0.5240	< 0.0001	0.3950
Asian sub-group
R vs. G	4	Random	53.73	58.72	53.73	41.28	0.88	0.66–1.17	0.0180	0.2190	0.3680
G vs. R	4	Random	46.27	41.28	46.27	58.72	1.14	0.86–1.52	0.0180	0.2190	0.3680
RR vs. RG + GG	4	Random	28.91	36.21	28.91	63.79	0.77	0.51–1.16	0.0400	0.3050	0.2090
RG vs. RR + GG	4	Fixed	49.64	45.03	49.64	54.97	1.10	0.93–1.31	0.2030	0.1470	0.2600
GG vs. RR + RG	4	Fixed	21.45	18.76	21.45	81.24	1.09	0.88–1.34	0.4350	0.3550	0.0710
Caucasian sub-group
R vs. G	4	Random	91.35	96.31	91.35	3.69	0.43	0.19–0.96	0.0240	0.6820	0.0400
G vs. R	4	Random	8.65	3.69	8.65	96.31	2.35	1.03–5.37	0.0240	0.6820	0.0400
RR vs. RG + GG	4	Random	83.82	92.99	83.82	7.01	0.42	0.19–0.93	0.0380	0.6540	0.0330
RG vs. RR + GG	4	Random	15.06	6.63	15.06	93.37	2.32	1.08–5.00	0.0600	0.5980	0.0310
GG vs. RR + RG	4	Fixed	1.12	0.38	1.12	99.62	1.57	0.33–7.46	0.3960	< 0.0001	0.5700

NS number of studies, OR odd ratio, CI confidence interval, pH p heterogeneity, pE p egger