Allele and genotype | NS | Model | Value | Sensitivity (%) | Specificity (%) | OR | 95%CI | pH | pE | p | |
---|---|---|---|---|---|---|---|---|---|---|---|
Case (%) | Control (%) | ||||||||||
Overall analysis | |||||||||||
R vs. G | 8 | Random | 62.76 | 71.83 | 62.76 | 28.17 | 0.69 | 0.51–0.95 | 0.0010 | 0.3230 | 0.0240 |
G vs. R | 8 | Random | 37.24 | 28.17 | 37.24 | 71.83 | 1.44 | 1.05–1.98 | 0.0010 | 0.3230 | 0.0240 |
RR vs. RG + GG | 8 | Random | 42.09 | 56.01 | 42.09 | 43.99 | 0.60 | 0.41–0.89 | 0.0040 | 0.4150 | 0.0120 |
RG vs. RR + GG | 8 | Random | 41.34 | 31.64 | 41.34 | 68.36 | 1.48 | 1.05–2.09 | 0.0120 | 0.3360 | 0.0260 |
GG vs. RR + RG | 8 | Fixed | 16.57 | 12.35 | 16.57 | 87.65 | 1.09 | 0.89–1.35 | 0.5240 | < 0.0001 | 0.3950 |
Asian sub-group | |||||||||||
R vs. G | 4 | Random | 53.73 | 58.72 | 53.73 | 41.28 | 0.88 | 0.66–1.17 | 0.0180 | 0.2190 | 0.3680 |
G vs. R | 4 | Random | 46.27 | 41.28 | 46.27 | 58.72 | 1.14 | 0.86–1.52 | 0.0180 | 0.2190 | 0.3680 |
RR vs. RG + GG | 4 | Random | 28.91 | 36.21 | 28.91 | 63.79 | 0.77 | 0.51–1.16 | 0.0400 | 0.3050 | 0.2090 |
RG vs. RR + GG | 4 | Fixed | 49.64 | 45.03 | 49.64 | 54.97 | 1.10 | 0.93–1.31 | 0.2030 | 0.1470 | 0.2600 |
GG vs. RR + RG | 4 | Fixed | 21.45 | 18.76 | 21.45 | 81.24 | 1.09 | 0.88–1.34 | 0.4350 | 0.3550 | 0.0710 |
Caucasian sub-group | |||||||||||
R vs. G | 4 | Random | 91.35 | 96.31 | 91.35 | 3.69 | 0.43 | 0.19–0.96 | 0.0240 | 0.6820 | 0.0400 |
G vs. R | 4 | Random | 8.65 | 3.69 | 8.65 | 96.31 | 2.35 | 1.03–5.37 | 0.0240 | 0.6820 | 0.0400 |
RR vs. RG + GG | 4 | Random | 83.82 | 92.99 | 83.82 | 7.01 | 0.42 | 0.19–0.93 | 0.0380 | 0.6540 | 0.0330 |
RG vs. RR + GG | 4 | Random | 15.06 | 6.63 | 15.06 | 93.37 | 2.32 | 1.08–5.00 | 0.0600 | 0.5980 | 0.0310 |
GG vs. RR + RG | 4 | Fixed | 1.12 | 0.38 | 1.12 | 99.62 | 1.57 | 0.33–7.46 | 0.3960 | < 0.0001 | 0.5700 |