Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

Egyptian Journal of Medical Human Genetics

Table 5 Summary of the correlation between A986S gene polymorphism and the risk of urolithiasis

Allele and genotype	NS	Model	Value		Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Allele and genotype	NS	Model	Case (%)	Control (%)	Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Overall analysis
A vs. S	9	Random	92.19	92.79	92.19	7.21	0.64	0.49–0.84	0.0250	0.2910	0.0010
S vs. A	9	Random	7.81	7.21	7.81	92.79	1.56	1.19–2.04	0.0250	0.2910	0.0010
AA vs. AS + SS	9	Random	85.85	86.30	85.85	13.70	0.66	0.48–0.91	0.0110	0.3580	0.0110
AS vs. AA + SS	9	Random	12.70	12.97	12.70	87.03	1.34	0.95–1.88	0.0040	0.4070	0.0990
SS vs. AA + AS	9	Fixed	1.46	0.73	1.46	99.27	3.34	1.85–6.02	0.5040	< 0.0001	< 0.0001
Asian sub-group
A vs. S	6	Fixed	94.32	95.95	94.32	4.05	0.55	0.44–0.70	0.2120	0.2020	< 0.0001
S vs. A	6	Fixed	5.68	4.05	5.68	95.95	1.81	1.43–2.29	0.2120	0.2020	< 0.0001
AA vs. AS + SS	6	Random	88.98	91.97	88.98	8.03	0.56	0.38–0.82	0.0710	0.3300	0.0030
AS vs. AA + SS	6	Random	10.68	7.95	10.68	92.05	1.71	1.16–2.53	0.0680	0.3370	0.0070
SS vs. AA + AS	6	Fixed	0.34	0.07	0.34	99.93	2.67	0.71–10.03	0.9770	< 0.0001	0.1450
Caucasian sub-group
A vs. S	3	Random	80.19	86.38	80.19	13.62	0.77	0.45–1.30	0.0130	0.4070	0.3200
S vs. A	3	Random	19.81	13.62	19.81	86.38	1.31	0.77–2.21	0.0130	0.4070	0.3200
AA vs. AS + SS	3	Random	68.14	74.82	68.14	25.18	0.86	0.53–1.42	0.0660	0.3470	0.5630
AS vs. AA + SS	3	Fixed	24.10	23.13	24.10	76.87	0.94	0.69–1.28	0.4030	< 0.0001	0.6840
SS vs. AA + AS	3	Random	7.76	2.05	7.76	97.95	3.10	1.00–9.64	0.0570	0.8070	0.0510

NS number of studies, OR odd ratio, CI confidence interval, pH p heterogeneity, pE p egger