Association between calcium-sensing receptor (CaSR) R990G, CaSR A986S, and CaSR Q1011E gene polymorphisms and the risk of urolithiasis: a meta-analysis

Egyptian Journal of Medical Human Genetics

Table 6 Summary of the association between Q1011E gene polymorphism and the risk of urolithiasis

Allele and genotype	NS	Model	Value		Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Allele and genotype	NS	Model	Case (%)	Control (%)	Sensitivity (%)	Specificity (%)	OR	95%CI	pH	pE	p
Overall analysis
Q vs. E	5	Fixed	97.03	97.73	97.03	2.27	0.77	0.51–1.16	0.1710	0.3770	0.2110
E vs. Q	5	Fixed	2.97	2.27	2.97	97.73	1.30	0.86–1.95	0.1710	0.3770	0.2110
QQ vs. QE + EE	5	Fixed	94.23	95.56	94.23	4.44	0.77	0.50–1.17	0.1560	0.4090	0.2150
QE vs. QQ + EE	5	Fixed	5.59	4.34	5.59	95.66	1.30	0.85–2.00	0.1550	0.4160	0.2290
EE vs. QQ + QE	5	Fixed	0.18	0.10	0.18	99.90	1.41	0.13–15.80	0.7820	1.0000	< 0.0001
Asian sub-group
Q vs. E	3	Fixed	97.72	98.52	97.72	1.48	0.69	0.41–1.17	0.2910	0.2580	0.1660
E vs. Q	3	Fixed	2.28	1.48	2.28	98.52	1.45	0.86–2.44	0.2910	0.2580	0.1660
QQ vs. QE + EE	3	Fixed	94.45	97.04	94.45	2.96	0.69	0.41–1.16	0.2870	0.2680	0.1610
QE vs. QQ + EE	3	Fixed	4.55	2.96	4.55	97.04	1.46	0.86–2.47	0.2870	0.2680	0.1610
EE vs. QQ + QE	3	NA	0.00	0.00	0.00	100.00	NA	NA	NA	NA	NA
Caucasian sub-group
Q vs. E	2	Random	93.87	94.86	93.87	5.14	1.00	0.29–3.51	0.0610	0.7650	0.9980
E vs. Q	2	Random	6.13	5.14	6.13	94.86	1.00	0.29–3.49	0.0610	0.7650	0.9980
QQ vs. QE + EE	2	Random	88.73	90.19	88.73	9.81	0.99	0.26–3.83	0.0550	0.8310	0.9920
QE vs. QQ + EE	2	Random	10.29	9.35	10.29	90.65	1.01	0.26–4.01	0.0570	0.8460	0.9880
EE vs. QQ + QE	2	Fixed	0.98	0.47	0.98	99.53	1.41	0.13–15.80	1.0000	< 0.0001	0.7820

NS number of studies, OR odd ratio, CI confidence interval, pH p heterogeneity, pE p egger, NS not available