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Egyptian Journal of Medical Human Genetics

Table 1 Summary estimates for the odds ratio (OR) of BsmI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Gene

Genetic contrast

Fixed effect OR (95% CI), p

Random effect OR (95% CI), p

Heterogeneity p value (Q test)

I2 (%)

Publication bias (p of Egger’s test)

Overall (65)

Allele contrast (b vs. B)

0.90 (0.85–0.94), < 0.001

0.89 (0.78–1.01), 0.09

< 0.001

82.02

0.73

Dominant (bb + Bb vs. BB)

0.84 (0.77–0.92), < 0.001

0.81 (0.68–0.97), 0.02

< 0.001

65.61

0.34

Homozygote (bb vs. BB)

0.81 (0.73–0.90), < 0.001

0.77 (0.60–0.99), 0.04

< 0.001

76.01

0.58

Co-dominant (Bb vs. BB)

0.88 (0.80–0.97), 0.01

0.85 (0.73–0.98), 0.03

< 0.001

43.51

0.33

Recessive (BB + Bb vs. bb)

0.89 (0.83–0.96), 0.004

0.88 (0.74–1.06), 0.20

< 0.001

77.37

0.94

Asian (22)

Allele Contrast (b vs. B)

0.84 (0.74–0.95), 0.008

0.86 (0.61–1.19), 0.36

< 0.001

81.58

0.92

Dominant (bb + Bb vs. BB)

0.70 (0.55–0.90), 0.005

0.70 (0.46–1.06), 0.09

0.007

47.66

0.91

Homozygote (bb vs. BB)

0.63 (0.47–0.84), 0.002

0.64 (0.34–1.22), 0.17

< 0.001

68.37

0.70

Co-dominant (Bb vs. BB)

0.77 (0.59–1.00), 0.05

0.75 (0.58–0.98), 0.03

0.84

0

0.79

Recessive (BB + Bb vs. bb)

0.86 (0.72–1.03), 0.10

0.84 (0.56–1.27), 0.42

< 0.001

75.82

0.78

Caucasian (37)

Allele contrast (b vs. B)

0.87 (0.82–0.92), < 0.001

0.86 (0.74–1.00), 0.05

< 0.001

81.09

0.74

Dominant (bb + Bb vs. BB)

0.85 (0.77–0.94), 0.003

0.84 (0.69–1.04), 0.11

< 0.001

69.26

0.57

Homozygote (bb vs. BB)

0.78 (0.69–0.88), < 0.001

0.76 (0.57–1.02), 0.06

< 0.001

77.36

0.63

Co-dominant (Bb vs. BB)

0.91 (0.82–1.02), 0.11

0.90 (0.75–1.08), 0.29

< 0.001

52.43

0.72

Recessive (BB + Bb vs. bb)

0.82 (0.75–0.90), < 0.001

0.81 (0.66–1.00), 0.05

< 0.001

75.5

0.72

Other (6)

Allele contrast (b vs. B)

1.28 (1.08–1.51), 0.003

1.19 (0.76–1.85), 0.43

< 0.001

84.7

0.45

Dominant (bb + Bb vs. BB)

1.00 (0.75–1.33), 0.96

0.82 (0.40–1.67), 0.59

< 0.001

80.11

0.31

Homozygote (bb vs. BB)

1.50 (1.08–2.10), 0.01

1.27 (0.54–3.00), 0.57

< 0.001

80.65

0.54

Co-dominant (Bb vs. BB)

0.77 (0.57–1.05), 0.10

0.62 (0.31–1.24), 0.18

< 0.001

75.66

0.17

Recessive (BB + Bb vs. bb)

1.69 (1.32–2.16), < 0.001

1.71 (0.97–3.03), 0.06

< 0.001

78.25

0.79

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