Skip to main content

Table 1 Summary estimates for the odds ratio (OR) of BsmI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

GeneGenetic contrastFixed effect OR (95% CI), pRandom effect OR (95% CI), pHeterogeneity p value (Q test)I2 (%)Publication bias (p of Egger’s test)
Overall (65)Allele contrast (b vs. B)0.90 (0.85–0.94), < 0.0010.89 (0.78–1.01), 0.09< 0.00182.020.73
Dominant (bb + Bb vs. BB)0.84 (0.77–0.92), < 0.0010.81 (0.68–0.97), 0.02< 0.00165.610.34
Homozygote (bb vs. BB)0.81 (0.73–0.90), < 0.0010.77 (0.60–0.99), 0.04< 0.00176.010.58
Co-dominant (Bb vs. BB)0.88 (0.80–0.97), 0.010.85 (0.73–0.98), 0.03< 0.00143.510.33
Recessive (BB + Bb vs. bb)0.89 (0.83–0.96), 0.0040.88 (0.74–1.06), 0.20< 0.00177.370.94
Asian (22)Allele Contrast (b vs. B)0.84 (0.74–0.95), 0.0080.86 (0.61–1.19), 0.36< 0.00181.580.92
Dominant (bb + Bb vs. BB)0.70 (0.55–0.90), 0.0050.70 (0.46–1.06), 0.090.00747.660.91
Homozygote (bb vs. BB)0.63 (0.47–0.84), 0.0020.64 (0.34–1.22), 0.17< 0.00168.370.70
Co-dominant (Bb vs. BB)0.77 (0.59–1.00), 0.050.75 (0.58–0.98), 0.030.8400.79
Recessive (BB + Bb vs. bb)0.86 (0.72–1.03), 0.100.84 (0.56–1.27), 0.42< 0.00175.820.78
Caucasian (37)Allele contrast (b vs. B)0.87 (0.82–0.92), < 0.0010.86 (0.74–1.00), 0.05< 0.00181.090.74
Dominant (bb + Bb vs. BB)0.85 (0.77–0.94), 0.0030.84 (0.69–1.04), 0.11< 0.00169.260.57
Homozygote (bb vs. BB)0.78 (0.69–0.88), < 0.0010.76 (0.57–1.02), 0.06< 0.00177.360.63
Co-dominant (Bb vs. BB)0.91 (0.82–1.02), 0.110.90 (0.75–1.08), 0.29< 0.00152.430.72
Recessive (BB + Bb vs. bb)0.82 (0.75–0.90), < 0.0010.81 (0.66–1.00), 0.05< 0.00175.50.72
Other (6)Allele contrast (b vs. B)1.28 (1.08–1.51), 0.0031.19 (0.76–1.85), 0.43< 0.00184.70.45
Dominant (bb + Bb vs. BB)1.00 (0.75–1.33), 0.960.82 (0.40–1.67), 0.59< 0.00180.110.31
Homozygote (bb vs. BB)1.50 (1.08–2.10), 0.011.27 (0.54–3.00), 0.57< 0.00180.650.54
Co-dominant (Bb vs. BB)0.77 (0.57–1.05), 0.100.62 (0.31–1.24), 0.18< 0.00175.660.17
Recessive (BB + Bb vs. bb)1.69 (1.32–2.16), < 0.0011.71 (0.97–3.03), 0.06< 0.00178.250.79