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Table 2 Summary estimates for the odds ratio (OR) of ApaI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

GeneGenetic contrastFixed effect OR (95% CI), pRandom effect OR (95% CI), pHeterogeneity p value (Q test)I2 (%)Publication bias (p of Egger’s test)
Overall (31)Allele contrast (a vs. A)0.99 (0.92–1.06), 0.901.01 (0.87–1.17), 0.86< 0.00174.820.79
Dominant (aa+Aa vs. AA)0.92 (0.82–1.04), 0.200.95 (0.78–1.14), 0.60< 0.00155.280.17
Homozygote (aa vs. AA)0.96 (0.83–1.11), 0.600.97 (0.72–1.30), 0.84< 0.00168.580.65
Co-dominant (Aa vs. AA)0.92 (0.81–1.04), 0.210.93 (0.79–1.09), 0.400.05131.30.09
Recessive (AA+Aa vs. aa)1.06 (0.94–1.18), 0.301.02 (0.81–1.28), 0.83< 0.00168.950.50
Asian (12)Allele contrast (a vs. A)0.99 (0.89–1.12), 0.991.10 (0.84–1.45), 0.46< 0.00178.480.32
Dominant (aa+Aa vs. AA)1.01 (0.82–1.24), 0.901.09 (0.81–1.49), 0.540.0543.750.04
Homozygote (aa vs. AA)0.90 (0.71–1.15), 0.431.03 (0.64–1.65), 0.890.00460.160.32
Co-dominant (Aa vs. AA)1.14 (0.91–1.44), 0.241.12 (0.89–1.41), 0.320.8300.007
Recessive (AA+Aa vs. aa)0.99 (0.83–1.17), 0.901.01 (0.70–1.46), 0.93< 0.00172.920.82
Caucasian (15)Allele contrast (a vs. A)0.96 (0.86–1.06), 0.450.92 (0.72–1.18), 0.54< 0.00178.000.49
Dominant (aa+Aa vs. AA)0.91 (0.77–1.08), 0.310.90 (0.66–1.23), 0.52< 0.00167.830.81
Homozygote (aa vs. AA)0.94 (0.76–1.17), 0.620.86 (0.52–1.42), 0.57< 0.00175.960.57
Co-dominant (Aa vs. AA)0.91 (0.77–1.09), 0.340.91 (0.70–1.19), 0.520.01449.930.96
Recessive (AA+Aa vs. aa)0.98 (0.81–1.18), 0.870.88 (0.61–1.28), 0.53< 0.00168.330.42
Other (4)Allele contrast (a vs. A)1.07 (0.91–1.26), 0.381.07 (0.90–1.27), 0.390.365.320.76
Dominant (aa+Aa vs. AA)0.82 (0.63–1.07), 0.150.82 (0.62–1.07), 0.150.4300.48
Homozygote (aa vs. AA)1.11 (0.79–1.55), 0.521.17 (0.64–1.13), 0.600.0365.550.44
Co-dominant (Aa vs. AA)0.67 (0.50–0.89), 0.0070.67 (0.50–0.89), 0.0070.6300.68
Recessive (AA+Aa vs. aa)1.42 (1.10–1.83), 0.0071.49 (1.00–2.23), 0.040.0952.40.38