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Table 2 Summary estimates for the odds ratio (OR) of ApaI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Gene Genetic contrast Fixed effect OR (95% CI), p Random effect OR (95% CI), p Heterogeneity p value (Q test) I2 (%) Publication bias (p of Egger’s test)
Overall (31) Allele contrast (a vs. A) 0.99 (0.92–1.06), 0.90 1.01 (0.87–1.17), 0.86 < 0.001 74.82 0.79
Dominant (aa+Aa vs. AA) 0.92 (0.82–1.04), 0.20 0.95 (0.78–1.14), 0.60 < 0.001 55.28 0.17
Homozygote (aa vs. AA) 0.96 (0.83–1.11), 0.60 0.97 (0.72–1.30), 0.84 < 0.001 68.58 0.65
Co-dominant (Aa vs. AA) 0.92 (0.81–1.04), 0.21 0.93 (0.79–1.09), 0.40 0.051 31.3 0.09
Recessive (AA+Aa vs. aa) 1.06 (0.94–1.18), 0.30 1.02 (0.81–1.28), 0.83 < 0.001 68.95 0.50
Asian (12) Allele contrast (a vs. A) 0.99 (0.89–1.12), 0.99 1.10 (0.84–1.45), 0.46 < 0.001 78.48 0.32
Dominant (aa+Aa vs. AA) 1.01 (0.82–1.24), 0.90 1.09 (0.81–1.49), 0.54 0.05 43.75 0.04
Homozygote (aa vs. AA) 0.90 (0.71–1.15), 0.43 1.03 (0.64–1.65), 0.89 0.004 60.16 0.32
Co-dominant (Aa vs. AA) 1.14 (0.91–1.44), 0.24 1.12 (0.89–1.41), 0.32 0.83 0 0.007
Recessive (AA+Aa vs. aa) 0.99 (0.83–1.17), 0.90 1.01 (0.70–1.46), 0.93 < 0.001 72.92 0.82
Caucasian (15) Allele contrast (a vs. A) 0.96 (0.86–1.06), 0.45 0.92 (0.72–1.18), 0.54 < 0.001 78.00 0.49
Dominant (aa+Aa vs. AA) 0.91 (0.77–1.08), 0.31 0.90 (0.66–1.23), 0.52 < 0.001 67.83 0.81
Homozygote (aa vs. AA) 0.94 (0.76–1.17), 0.62 0.86 (0.52–1.42), 0.57 < 0.001 75.96 0.57
Co-dominant (Aa vs. AA) 0.91 (0.77–1.09), 0.34 0.91 (0.70–1.19), 0.52 0.014 49.93 0.96
Recessive (AA+Aa vs. aa) 0.98 (0.81–1.18), 0.87 0.88 (0.61–1.28), 0.53 < 0.001 68.33 0.42
Other (4) Allele contrast (a vs. A) 1.07 (0.91–1.26), 0.38 1.07 (0.90–1.27), 0.39 0.36 5.32 0.76
Dominant (aa+Aa vs. AA) 0.82 (0.63–1.07), 0.15 0.82 (0.62–1.07), 0.15 0.43 0 0.48
Homozygote (aa vs. AA) 1.11 (0.79–1.55), 0.52 1.17 (0.64–1.13), 0.60 0.03 65.55 0.44
Co-dominant (Aa vs. AA) 0.67 (0.50–0.89), 0.007 0.67 (0.50–0.89), 0.007 0.63 0 0.68
Recessive (AA+Aa vs. aa) 1.42 (1.10–1.83), 0.007 1.49 (1.00–2.23), 0.04 0.09 52.4 0.38