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Egyptian Journal of Medical Human Genetics

Table 2 Summary estimates for the odds ratio (OR) of ApaI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Gene

Genetic contrast

Fixed effect OR (95% CI), p

Random effect OR (95% CI), p

Heterogeneity p value (Q test)

I2 (%)

Publication bias (p of Egger’s test)

Overall (31)

Allele contrast (a vs. A)

0.99 (0.92–1.06), 0.90

1.01 (0.87–1.17), 0.86

< 0.001

74.82

0.79

Dominant (aa+Aa vs. AA)

0.92 (0.82–1.04), 0.20

0.95 (0.78–1.14), 0.60

< 0.001

55.28

0.17

Homozygote (aa vs. AA)

0.96 (0.83–1.11), 0.60

0.97 (0.72–1.30), 0.84

< 0.001

68.58

0.65

Co-dominant (Aa vs. AA)

0.92 (0.81–1.04), 0.21

0.93 (0.79–1.09), 0.40

0.051

31.3

0.09

Recessive (AA+Aa vs. aa)

1.06 (0.94–1.18), 0.30

1.02 (0.81–1.28), 0.83

< 0.001

68.95

0.50

Asian (12)

Allele contrast (a vs. A)

0.99 (0.89–1.12), 0.99

1.10 (0.84–1.45), 0.46

< 0.001

78.48

0.32

Dominant (aa+Aa vs. AA)

1.01 (0.82–1.24), 0.90

1.09 (0.81–1.49), 0.54

0.05

43.75

0.04

Homozygote (aa vs. AA)

0.90 (0.71–1.15), 0.43

1.03 (0.64–1.65), 0.89

0.004

60.16

0.32

Co-dominant (Aa vs. AA)

1.14 (0.91–1.44), 0.24

1.12 (0.89–1.41), 0.32

0.83

0

0.007

Recessive (AA+Aa vs. aa)

0.99 (0.83–1.17), 0.90

1.01 (0.70–1.46), 0.93

< 0.001

72.92

0.82

Caucasian (15)

Allele contrast (a vs. A)

0.96 (0.86–1.06), 0.45

0.92 (0.72–1.18), 0.54

< 0.001

78.00

0.49

Dominant (aa+Aa vs. AA)

0.91 (0.77–1.08), 0.31

0.90 (0.66–1.23), 0.52

< 0.001

67.83

0.81

Homozygote (aa vs. AA)

0.94 (0.76–1.17), 0.62

0.86 (0.52–1.42), 0.57

< 0.001

75.96

0.57

Co-dominant (Aa vs. AA)

0.91 (0.77–1.09), 0.34

0.91 (0.70–1.19), 0.52

0.014

49.93

0.96

Recessive (AA+Aa vs. aa)

0.98 (0.81–1.18), 0.87

0.88 (0.61–1.28), 0.53

< 0.001

68.33

0.42

Other (4)

Allele contrast (a vs. A)

1.07 (0.91–1.26), 0.38

1.07 (0.90–1.27), 0.39

0.36

5.32

0.76

Dominant (aa+Aa vs. AA)

0.82 (0.63–1.07), 0.15

0.82 (0.62–1.07), 0.15

0.43

0

0.48

Homozygote (aa vs. AA)

1.11 (0.79–1.55), 0.52

1.17 (0.64–1.13), 0.60

0.03

65.55

0.44

Co-dominant (Aa vs. AA)

0.67 (0.50–0.89), 0.007

0.67 (0.50–0.89), 0.007

0.63

0

0.68

Recessive (AA+Aa vs. aa)

1.42 (1.10–1.83), 0.007

1.49 (1.00–2.23), 0.04

0.09

52.4

0.38

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