Gene | Genetic contrast | Fixed effect OR (95% CI), p | Random effect OR (95% CI), p | Heterogeneity p value (Q test) | I2 (%) | Publication bias (p of Egger’s test) |
---|---|---|---|---|---|---|
Overall (18) | Allele contrast (f vs. F) | 1.19 (1.08–1.31), < 0.001 | 1.13 (0.95–1.34), 0.15 | < 0.001 | 61.8 | 0.64 |
Dominant (ff + Ff vs. FF) | 1.19 (1.04–1.36), 0.01 | 1.13 (0.94–1.37), 0.18 | 0.04 | 39.36 | 0.40 | |
Homozygote (ff vs. FF) | 1.47 (1.19–1.83), < 0.001 | 1.38 (0.92–2.05), 0.11 | < 0.001 | 62.08 | 0.99 | |
Co-dominant (Ff vs. FF) | 1.12 (0.97–1.30), 0.11 | 1.10 (0.93–1.29), 0.24 | 0.29 | 13.69 | 0.15 | |
Recessive (FF + Ff vs. ff) | 1.40 (1.15–1.72), < 0.001 | 1.34 (0.94–1.91), 0.10 | 0.001 | 57.98 | 0.69 | |
Asian (5) | Allele contrast (f vs. F) | 1.28 (1.07–1.53), 0.007 | 1.17 (0.76–1.82), 0.45 | < 0.001 | 79.79 | 0.50 |
Dominant (ff + Ff vs. FF) | 1.24 (0.96–1.59), 0.08 | 1.16 (0.71–1.89), 0.53 | 0.02 | 65.88 | 0.61 | |
Homozygote (ff vs. FF) | 1.73 (1.18–2.52), 0.004 | 1.68 (0.68–4.14), 0.25 | < 0.001 | 78.92 | 0.88 | |
Co-dominant (Ff vs. FF) | 1.15 (0.87–1.52), 0.30 | 1.09 (0.70–1.70), 0.69 | 0.12 | 45.24 | 0.36 | |
Recessive (FF + Ff vs. ff) | 1.66 (1.16–2.37), 0.005 | 1.60 (0.76–3.37), 0.21 | 0.004 | 73.74 | 0.88 | |
Caucasian (10) | Allele contrast (f vs. F) | 1.31 (0.99–1.29), 0.06 | 1.05 (0.86–1.29), 0.61 | 0.04 | 48.84 | 0.78 |
Dominant (ff + Ff vs. FF) | 1.15 (0.96–1.38), 0.12 | 1.07 (0.83–1.39), 0.57 | 0.09 | 39.58 | 0.65 | |
Homozygote (ff vs. FF) | 1.27 (0.95–1.70), 0.10 | 1.11 (0.73–1.70), 0.61 | 0.09 | 39.35 | 0.28 | |
Co-dominant (Ff vs. FF) | 1.11 (0.91–1.34), 0.27 | 1.07 (0.85–1.35), 0.54 | 0.22 | 23.34 | 0.63 | |
Recessive (FF + Ff vs. ff) | 1.21 (0.92–1.59), 0.15 | 1.12 (0.78–1.61), 0.53 | 0.17 | 29.92 | 0.44 | |
Other (3) | Allele contrast (f vs. F) | 1.26 (0.97–1.64), 0.08 | 1.31 (0.84–2.04), 0.21 | 0.07 | 60.97 | 0.58 |
Dominant (ff + Ff vs. FF) | 1.24 (0.86–1.77), 0.23 | 1.24 (0.86–1.77), 0.23 | 0.62 | 0 | 0.82 | |
Homozygote (ff vs. FF) | 1.91 (1.00–3.65), 0.05 | 3.28 (0.51–20.87), 0.20 | 0.01 | 78.17 | 0.07 | |
Co-dominant (Ff vs. FF) | 1.11 (0.76–1.61), 0.56 | 1.11 (0.76–1.61), 0.56 | 0.74 | 0 | 0.07 | |
Recessive (FF + Ff vs. ff) | 1.72 (0.96–3.05), 0.06 | 3.30 (0.49–22.00), 0.21 | 0.005 | 81.08 | 0.001 |