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Table 3 Summary estimates for the odds ratio (OR) of FokI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Gene

Genetic contrast

Fixed effect OR (95% CI), p

Random effect OR (95% CI), p

Heterogeneity p value (Q test)

I2 (%)

Publication bias (p of Egger’s test)

Overall (18)

Allele contrast (f vs. F)

1.19 (1.08–1.31), < 0.001

1.13 (0.95–1.34), 0.15

< 0.001

61.8

0.64

Dominant (ff + Ff vs. FF)

1.19 (1.04–1.36), 0.01

1.13 (0.94–1.37), 0.18

0.04

39.36

0.40

Homozygote (ff vs. FF)

1.47 (1.19–1.83), < 0.001

1.38 (0.92–2.05), 0.11

< 0.001

62.08

0.99

Co-dominant (Ff vs. FF)

1.12 (0.97–1.30), 0.11

1.10 (0.93–1.29), 0.24

0.29

13.69

0.15

Recessive (FF + Ff vs. ff)

1.40 (1.15–1.72), < 0.001

1.34 (0.94–1.91), 0.10

0.001

57.98

0.69

Asian (5)

Allele contrast (f vs. F)

1.28 (1.07–1.53), 0.007

1.17 (0.76–1.82), 0.45

< 0.001

79.79

0.50

Dominant (ff + Ff vs. FF)

1.24 (0.96–1.59), 0.08

1.16 (0.71–1.89), 0.53

0.02

65.88

0.61

Homozygote (ff vs. FF)

1.73 (1.18–2.52), 0.004

1.68 (0.68–4.14), 0.25

< 0.001

78.92

0.88

Co-dominant (Ff vs. FF)

1.15 (0.87–1.52), 0.30

1.09 (0.70–1.70), 0.69

0.12

45.24

0.36

Recessive (FF + Ff vs. ff)

1.66 (1.16–2.37), 0.005

1.60 (0.76–3.37), 0.21

0.004

73.74

0.88

Caucasian (10)

Allele contrast (f vs. F)

1.31 (0.99–1.29), 0.06

1.05 (0.86–1.29), 0.61

0.04

48.84

0.78

Dominant (ff + Ff vs. FF)

1.15 (0.96–1.38), 0.12

1.07 (0.83–1.39), 0.57

0.09

39.58

0.65

Homozygote (ff vs. FF)

1.27 (0.95–1.70), 0.10

1.11 (0.73–1.70), 0.61

0.09

39.35

0.28

Co-dominant (Ff vs. FF)

1.11 (0.91–1.34), 0.27

1.07 (0.85–1.35), 0.54

0.22

23.34

0.63

Recessive (FF + Ff vs. ff)

1.21 (0.92–1.59), 0.15

1.12 (0.78–1.61), 0.53

0.17

29.92

0.44

Other (3)

Allele contrast (f vs. F)

1.26 (0.97–1.64), 0.08

1.31 (0.84–2.04), 0.21

0.07

60.97

0.58

Dominant (ff + Ff vs. FF)

1.24 (0.86–1.77), 0.23

1.24 (0.86–1.77), 0.23

0.62

0

0.82

Homozygote (ff vs. FF)

1.91 (1.00–3.65), 0.05

3.28 (0.51–20.87), 0.20

0.01

78.17

0.07

Co-dominant (Ff vs. FF)

1.11 (0.76–1.61), 0.56

1.11 (0.76–1.61), 0.56

0.74

0

0.07

Recessive (FF + Ff vs. ff)

1.72 (0.96–3.05), 0.06

3.30 (0.49–22.00), 0.21

0.005

81.08

0.001