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Table 3 Summary estimates for the odds ratio (OR) of FokI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

GeneGenetic contrastFixed effect OR (95% CI), pRandom effect OR (95% CI), pHeterogeneity p value (Q test)I2 (%)Publication bias (p of Egger’s test)
Overall (18)Allele contrast (f vs. F)1.19 (1.08–1.31), < 0.0011.13 (0.95–1.34), 0.15< 0.00161.80.64
Dominant (ff + Ff vs. FF)1.19 (1.04–1.36), 0.011.13 (0.94–1.37), 0.180.0439.360.40
Homozygote (ff vs. FF)1.47 (1.19–1.83), < 0.0011.38 (0.92–2.05), 0.11< 0.00162.080.99
Co-dominant (Ff vs. FF)1.12 (0.97–1.30), 0.111.10 (0.93–1.29), 0.240.2913.690.15
Recessive (FF + Ff vs. ff)1.40 (1.15–1.72), < 0.0011.34 (0.94–1.91), 0.100.00157.980.69
Asian (5)Allele contrast (f vs. F)1.28 (1.07–1.53), 0.0071.17 (0.76–1.82), 0.45< 0.00179.790.50
Dominant (ff + Ff vs. FF)1.24 (0.96–1.59), 0.081.16 (0.71–1.89), 0.530.0265.880.61
Homozygote (ff vs. FF)1.73 (1.18–2.52), 0.0041.68 (0.68–4.14), 0.25< 0.00178.920.88
Co-dominant (Ff vs. FF)1.15 (0.87–1.52), 0.301.09 (0.70–1.70), 0.690.1245.240.36
Recessive (FF + Ff vs. ff)1.66 (1.16–2.37), 0.0051.60 (0.76–3.37), 0.210.00473.740.88
Caucasian (10)Allele contrast (f vs. F)1.31 (0.99–1.29), 0.061.05 (0.86–1.29), 0.610.0448.840.78
Dominant (ff + Ff vs. FF)1.15 (0.96–1.38), 0.121.07 (0.83–1.39), 0.570.0939.580.65
Homozygote (ff vs. FF)1.27 (0.95–1.70), 0.101.11 (0.73–1.70), 0.610.0939.350.28
Co-dominant (Ff vs. FF)1.11 (0.91–1.34), 0.271.07 (0.85–1.35), 0.540.2223.340.63
Recessive (FF + Ff vs. ff)1.21 (0.92–1.59), 0.151.12 (0.78–1.61), 0.530.1729.920.44
Other (3)Allele contrast (f vs. F)1.26 (0.97–1.64), 0.081.31 (0.84–2.04), 0.210.0760.970.58
Dominant (ff + Ff vs. FF)1.24 (0.86–1.77), 0.231.24 (0.86–1.77), 0.230.6200.82
Homozygote (ff vs. FF)1.91 (1.00–3.65), 0.053.28 (0.51–20.87), 0.200.0178.170.07
Co-dominant (Ff vs. FF)1.11 (0.76–1.61), 0.561.11 (0.76–1.61), 0.560.7400.07
Recessive (FF + Ff vs. ff)1.72 (0.96–3.05), 0.063.30 (0.49–22.00), 0.210.00581.080.001