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Table 4 Summary estimates for the odds ratio (OR) of TaqI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

GeneGenetic ContrastFixed effect OR (95% CI), pRandom effect OR (95% CI), pHeterogeneity p value (Q test)I2 (%)Publication bias (p of Egger’s test)
Overall (26)Allele contrast (t vs. T)1.08 (0.99–1.17), 0.061.10 (0.91–1.32), 0.30< 0.00177.260.67
Dominant (tt + Tt vs. TT)1.05 (0.93–1.18), 0.381.09 (0.84–1.41), 0.48< 0.00175.220.47
Homozygote (tt vs. TT)1.18 (0.99–1.39), 0.051.20 (0.85–1.69), 0.29< 0.00170.170.76
Co-dominant (Tt vs. TT)1.01 (0.89–1.15), 0.841.04 (0.82–1.33), 0.70< 0.00168.060.51
Recessive (TT + Tt vs. tt)1.19 (1.02–1.38), 0.021.16 (0.91–1.48), 0.20< 0.00152.950.87
Asian (6)Allele contrast (t vs. T)0.94 (0.79–1.12), 0.490.99 (0.67–1.47), 0.990.00372.150.65
Dominant (tt + Tt vs. TT)0.84 (0.66–1.07), 0.170.92 (0.54–1.56), 0.760.00570.380.61
Homozygote (tt vs. TT)1.00 (0.69–1.43), 0.991.08 (0.52–2.23), 0.820.0358.570.70
Co-dominant (Tt vs. TT)0.80 (0.61–1.03), 0.090.86 (0.52–1.41), 0.550.02561.120.66
Recessive (TT + Tt vs. tt)1.09 (0.79–1.52), 0.581.11 (0.72–1.72), 0.620.2326.090.73
Caucasian (17)Allele contrast (t vs. T)1.24 (1.11–1.38), < 0.0011.22 (0.99–1.50), 0.05< 0.00171.320.69
Dominant (tt + Tt vs. TT)1.31 (1.12–1.53), < 0.0011.28 (0.95–1.74), 0.09< 0.00169.870.69
Homozygote (tt vs. TT)1.46 (1.18–1.82), < 0.0011.40 (0.94–2.09), 0.09< 0.00166.060.67
Co-dominant (Tt vs. TT)1.24 (1.05–1.47), 0.0091.22 (0.91–1.64), 0.16< 0.00163.750.67
Recessive (TT + Tt vs. tt)1.35 (1.11–1.63), 0.0021.28 (0.96–1.71), 0.080.0150.070.48
Other (3)Allele contrast (t vs. T)0.76 (0.62–0.94), 0.010.74 (0.39–1.39), 0.35< 0.00188.270.81
Dominant (tt + Tt vs. TT)0.69 (0.52–0.92), 0.010.65 (0.31–1.36), 0.44< 0.00171.340.65
Homozygote (tt vs. TT)0.66 (0.43–1.00), 0.050.63 (0.17–2.26), 0.48< 0.00186.460.84
Co-dominant (Tt vs. TT)0.70 (0.52–0.95), 0.020.67 (0.38–1.19), 0.170.03470.350.62
Recessive (TT + Tt vs. tt)0.77 (0.52–1.15), 0.050.76 (0.29–1.99), 0.580.00978.570.89