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Egyptian Journal of Medical Human Genetics

Table 4 Summary estimates for the odds ratio (OR) of TaqI in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric

From: Vitamin D receptor (VDR) gene FokI, BsmI, ApaI, and TaqI polymorphisms and osteoporosis risk: a meta-analysis

Gene

Genetic Contrast

Fixed effect OR (95% CI), p

Random effect OR (95% CI), p

Heterogeneity p value (Q test)

I2 (%)

Publication bias (p of Egger’s test)

Overall (26)

Allele contrast (t vs. T)

1.08 (0.99–1.17), 0.06

1.10 (0.91–1.32), 0.30

< 0.001

77.26

0.67

Dominant (tt + Tt vs. TT)

1.05 (0.93–1.18), 0.38

1.09 (0.84–1.41), 0.48

< 0.001

75.22

0.47

Homozygote (tt vs. TT)

1.18 (0.99–1.39), 0.05

1.20 (0.85–1.69), 0.29

< 0.001

70.17

0.76

Co-dominant (Tt vs. TT)

1.01 (0.89–1.15), 0.84

1.04 (0.82–1.33), 0.70

< 0.001

68.06

0.51

Recessive (TT + Tt vs. tt)

1.19 (1.02–1.38), 0.02

1.16 (0.91–1.48), 0.20

< 0.001

52.95

0.87

Asian (6)

Allele contrast (t vs. T)

0.94 (0.79–1.12), 0.49

0.99 (0.67–1.47), 0.99

0.003

72.15

0.65

Dominant (tt + Tt vs. TT)

0.84 (0.66–1.07), 0.17

0.92 (0.54–1.56), 0.76

0.005

70.38

0.61

Homozygote (tt vs. TT)

1.00 (0.69–1.43), 0.99

1.08 (0.52–2.23), 0.82

0.03

58.57

0.70

Co-dominant (Tt vs. TT)

0.80 (0.61–1.03), 0.09

0.86 (0.52–1.41), 0.55

0.025

61.12

0.66

Recessive (TT + Tt vs. tt)

1.09 (0.79–1.52), 0.58

1.11 (0.72–1.72), 0.62

0.23

26.09

0.73

Caucasian (17)

Allele contrast (t vs. T)

1.24 (1.11–1.38), < 0.001

1.22 (0.99–1.50), 0.05

< 0.001

71.32

0.69

Dominant (tt + Tt vs. TT)

1.31 (1.12–1.53), < 0.001

1.28 (0.95–1.74), 0.09

< 0.001

69.87

0.69

Homozygote (tt vs. TT)

1.46 (1.18–1.82), < 0.001

1.40 (0.94–2.09), 0.09

< 0.001

66.06

0.67

Co-dominant (Tt vs. TT)

1.24 (1.05–1.47), 0.009

1.22 (0.91–1.64), 0.16

< 0.001

63.75

0.67

Recessive (TT + Tt vs. tt)

1.35 (1.11–1.63), 0.002

1.28 (0.96–1.71), 0.08

0.01

50.07

0.48

Other (3)

Allele contrast (t vs. T)

0.76 (0.62–0.94), 0.01

0.74 (0.39–1.39), 0.35

< 0.001

88.27

0.81

Dominant (tt + Tt vs. TT)

0.69 (0.52–0.92), 0.01

0.65 (0.31–1.36), 0.44

< 0.001

71.34

0.65

Homozygote (tt vs. TT)

0.66 (0.43–1.00), 0.05

0.63 (0.17–2.26), 0.48

< 0.001

86.46

0.84

Co-dominant (Tt vs. TT)

0.70 (0.52–0.95), 0.02

0.67 (0.38–1.19), 0.17

0.034

70.35

0.62

Recessive (TT + Tt vs. tt)

0.77 (0.52–1.15), 0.05

0.76 (0.29–1.99), 0.58

0.009

78.57

0.89

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