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Table 2 The interpreted results of the risk assessment of various reported changes

From: Prediction and in silico validation of MYH7 gene missense variants in the Iranian population: a bioinformatics analysis based on Iranome database

VariantClinVarSIFTPolyphen2MutationTaster
p.Ala26ValBenignToleratedBenignDamaging
p.Pro211LeuUncertain significanceDamagingBenignTolerated
p.Arg787HisUncertain significanceToleratedBenignTolerated
p.Val964LeuConflicting interpretations of pathogenicityDamagingProbably damagingDamaging
p.Ala1191ThrToleratedBenignDamaging
p.Asn1257SerBenignToleratedBenignDamaging
p.Arg1277Gln Uncertain significanceDamagingBenignDamaging
p.Ser1366LeuDamagingBenignDamaging
p.Ser1491CysBenignDamagingBenignDamaging
p.Ser1596LeuDamagingBenignDamaging
p.Ala1603ThrUncertain significanceDamagingPossibly damagingDamaging
p.Arg1662HisUncertain significanceToleratedBenignTolerated
p.Asn1824AspToleratedBenignDamaging
p.Asn1824SerUncertain significanceToleratedBenignDamaging