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Table 1 Purinergic receptors in cancer

From: Purinergic signalling pathway: therapeutic target in ovarian cancer

S. no. Receptor subtypes Preferred natural ligand Role of purinergic receptors in ovarian cancer References
P1 Adenosine receptors [G protein coupled receptor]
 1. A1R Adenosine Immune activation and tumour suppression [31, 32]
 2. A2AR Adenosine Immune suppression and pro-tumour effects [33, 34]
 3. A2BR Adenosine Immune suppression and pro-tumour effects [33, 34]
 4. A3R Adenosine Immune activation and tumour suppression [31, 32]
P2 Purinergic receptors
1. P2X receptors [ligand-gated ion channel receptor]
 1. P2X1 ATP NA NA
 2. P2X2 ATP NA NA
 3. P2X3 ATP NA NA
 4. P2X4 ATP NA NA
 5. P2X5 ATP Cell differentiation [35]
 6. P2X6 ATP NA NA
 7. P2X7 ATP Cell differentiation [35]
2. P2Y receptors [G-protein-coupled receptor]
 1. P2Y1 ADP Tumour cell proliferation [35]
 2. P2Y2 ATP = UTP Tumour cell proliferation [35]
 3. P2Y4 UTP NA NA
 4. P2Y6 UDP NA NA
 5. P2Y11 ATP NA NA
 6. P2Y12 ADP EMT during cancer progression [36]
 7. P2Y13 ADP NA NA
 8. P2Y14 UDP - glucose NA NA
  1. ADP adenosine diphosphate, ATP adenosine triphosphate, EMT epithelial mesenchymal transittion, UDP uridine diphosphate, UMP uridine monophosphate, UTP uridinetriphosphate