Table 2 The association between three common XPC polymorphisms and the risk of age-related macular degeneration

PAT

Additive model

 -/-

33

31

1.0

–

–

1.0

–

–

 -/+

57

60

1.12

0.61–2.06

0.714

1.11

0.58–2.11

0.746

 +/+

28

29

1.10

0.54–2.25

0.789

0.92

0.44–1.95

0.846

Dominant model

 -/-

33

31

1.0

–

–

1.0

–

–

 -/+ and +/+

85

89

1.11

0.62–1.97

0.711

1.04

0.57–1.91

0.881

Recessive model

 -/- and -/+

90

91

1.0

–

–

1.0

–

–

 +/+

28

29

1.02

0.56–1.85

0.937

0.86

0.46–1.61

0.653

Minor allele frequency

0.4788

0.4917

1.05

0.73–1.50

0.779

Ala499Val

Additive model

 Ala/Ala

72

73

1.0

–

–

1.0

–

-

 Ala/Val

41

39

0.93

0.54–1.62

0.819

1.02

0.57–1.81

0.947

 Val/Val

5

8

1.57

0.49–5.05

0.442

1.48

0.45–4.92

0.515

Dominant model

 Ala/Ala

72

73

1.0

–

–

1.0

–

–

 Ala/Val + Val/Val

46

47

1.01

0.59-1.69

0.977

1.07

0.62–1.86

0.791

Recessive model

 Ala + Ala/Val

113

112

1.0

–

–

1.0

–

–

 Val/Val

5

8

1.61

0.51–5.08

0.413

1.47

0.45–4.80

0.517

Minor allele frequency

0.2161

0.2291

1.07

0.70–1.66

0.732

Lys939Gln

Additive model

 Lys/Lys

31

30

1.0

–

–

1.0

–

–

 Lys/Gln

58

61

1.08

0.58–2.01

0.792

1.04

0.54–1.99

0.899

 Gln/Gln

29

29

1.03

0.50–2.12

0.929

0.84

0.39–1.78

0.656

Dominant model

 Lys/Lys

31

30

1.0

–

–

1.0

–

–

 Lys/Gln + Gln/Gln

87

90

1.06

0.59–1.91

0.822

0.97

0.52–1.79

0.927

Recessive model

 Lys/Lys + Lys/Gln

89

91

1.0

–

–

1.0

–

–

 Gln/Gln

29

29

0.98

0.54–1.76

0.941

0.82

0.44–1.52

0.528

Minor allele frequency

0.4915

0.4958

1.01

0.71–1.45

0.925