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Egyptian Journal of Medical Human Genetics
Fig. 3 | Egyptian Journal of Medical Human Genetics

Fig. 3

From: Role of mesenchymal stem cells and their culture medium in alleviating kidney injury in rats diabetic nephropathy

Fig. 3

H&E stained renal cortex sections at magnification × 400, bar 25 μm. a Control group shows normal structure of glomeruli (G) with Bowman’s spaces (S) which is lined by visceral (V) and parietal (P) cells. Proximal tubules (PC) and distal tubules (DC) are also showed. b–d Renal cortex of diabetic nephropathy group (b) has distorted glomeruli with expanded Bowman space (arrow). The glomeruli showed foci of hyalinosis and eosinophilic deposits (curved arrow) while tubules show dark stained nuclei (arrows heads). c Some tubules are atrophied (TA); others are dilated (DT), and some are obliterated (OT). d Blood vessels have marked hyalinization (arrow head). Dark nuclei and a vacuolated cytoplasm (arrow) are seen within tubules. e Fibroblast group shows distorted shrunken glomeruli (G); blood vessels showed hyalinosis (arrow), and tubules show dark stained nuclei (arrow head). f ADMSC group shows marked improvement in the glomeruli (G), proximal tubules (PT), and distal tubules (DT). g Culture media group shows the glomeruli (G), proximal tubules (PC), and distal tubules (DC) appear nearly similar to that of the control

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