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Table 4 MRD study of all patients on day 15 regarding studied parameters

From: Clinical impact of early minimal residual disease detection at day 15 in precursor B-childhood acute lymphoblastic leukemia: an Egyptian experience

ParametersMRD result (Outcome at day 15)Fisher exact test
Good outcome, negative MRD (n= 44) 61.1%Bad outcome, positive MRD (n= 28) 38.8%PvalueSig.
N%N%
Studied cytogenetics at diagnosisPositive48.1%1242.8%< 0.001S
Negative4090.9%1657.2%
Risk classificationHigh risk1636.4%2485.7%< 0.001S
Standard risk2863.6%414.3%
Age< 124.5%621.4%0.036S
1–94091.0%621.4%
> 1024.5%1657.2%
SexMale1636.4%1864.2%0.104NS
Female2863.6%1035.8%
HepatomegalyAbsent2045.4%1242.8%0.257NS
Present2454.5%1657.2%
SplenomegalyAbsent2250.0%1450.0%0.228NS
Present2250.0%1450.0%
LymphadenopathyAbsent48.1%1242.8%1.000NS
Present4090.9%1657.2%
CNS infiltrationAbsent4295.5%2278.6%0.207NS
Present24.5%621.4%
Laboratory parameters
Parameters ttest
MeanSDMeanSDPvalueSig
Hb (gm/dL)8.321.447.550.910.178NS
TLC (× 109/L)1.790.761.130.510.027S
Platelets (× 109/L)102.3256.7461.7523.120.014S
BM blasts (%)1.930.8615.255.6< 0.001S
  1. N number, NS non-significant, S significance. P ≥ 0.05 = NS; P < 0.05 = S; P ˂ 0.01 = HS; SD standard deviation, TLC total leukocytic count, Hb hemoglobin, BM bone marrow