Prognostic significance of DNMT3a gene expression and reactive nitrogen species in newly diagnosed Egyptian de novo adult acute myeloid leukemia patients

Egyptian Journal of Medical Human Genetics

Table 2 Comparison between the two studied groups according to DNMT3A expression and NO level before and after treatment

	Cases		Control (n = 10)
	Before (n = 45)	After (n = 26)	Control (n = 10)
DNMT3A expression
Min.–Max.	18.60–83.60	2.96–71.20	0.54–1.72
Mean ± SD	46.64 ± 19.90	24.88 ± 21.39	0.94 ± 0.36
Median	46.50	17.05	0.98
Significance between groups	p₁ < 0.001^, p₂ < 0.001^, p₃ < 0.001^*
NO level
Min.–Max.	0.53–60.90	0.0–27.50	0.0–22.11
Mean ± SD	16.06 ± 13.90	8.81 ± 7.43	7.83 ± 7.35
Median	12.0	6.20	5.80
Significance between groups	p₁ = 0.008^, p₂ = 0.035^, p₃ = 0.538

p₁: P value for Wilcoxon signed-ranks test for comparing between before and after
p₂: P value for Mann-Whitney test for comparing between before and control
p₃: P value for Mann-Whitney test for comparing between after and control