Egyptian Journal of Medical Human Genetics

Table 3 Agreement (sensitivity, specificity) for different parameters to diagnose mutated cases cut-off point as described in the ROC curve

From: Prognostic significance of DNMT3a gene expression and reactive nitrogen species in newly diagnosed Egyptian de novo adult acute myeloid leukemia patients

	AUC	P	95% C.I	Cut-off	Sensitivity	Specificity	PPV	NPV
DNMT3A expression	0.683	0.063	0.50–0.87	>46.5	75.0	60.61	40.9	87.0
NO level	0.616	0.238	0.43–0.80	≤13.4	75.0	51.52	36.0	85.0

AUC area under a curve, P value probability value, CI confidence intervals, NPV negative predictive value, PPV positive predictive value

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