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Table 4 Comparison between low and high DNMT3a gene expressors with respect to their demographics as well as clinical data

From: Prognostic significance of DNMT3a gene expression and reactive nitrogen species in newly diagnosed Egyptian de novo adult acute myeloid leukemia patients

  Level of expression Test of sig. p
  Low expression
(n = 22)
High expression
(n = 23)
  No. % No. %
Sex
 Male 12 54.5 12 52.2 χ2 = 0.025 0.873
 Female 10 45.5 11 47.8
Age (years)
 Min.–Max. 20.0–72.0 20.0–78.0 t = 0.754 0.455
 Mean ± SD 44.05 ± 14.85 47.70 ± 17.47
 Median 42.50 53.0
Co-Morbidities
 None 16 72.7 14 60.9 χ2 = 0.927 MCp = 0.743
 Single 4 18.2 5 21.7
 Multiple 2 9.1 4 17.4
Cytogenetic
 Poor risk 4 57.1 3 42.9 χ2 = 3.012 MCp = 0.248
 Intermediate risk 15 60 10 40
 Good risk 4 44.4 9 55.6
Total leucocyte count
 Min.–Max. 1.0–152.0 1.0–236.0 U = 217.50 0.419
 Mean ± SD. 27.59 ± 37.82 45.48 ± 76.04
 Median 11.0 6.0
Hemoglobin
 Min.–Max. 4.0–12.0 5.0–12.0 t = 0.771 0.445
 Mean ± SD 7.27 ± 1.98 7.74 ± 2.07
 Median 8.0 8.0
Platelets
 Min.–Max 4.0–345.0 4.0–248.0 U = 242.50 0.812
 Mean ± SD 68.18 ± 80.60 60.91 ± 64.05
 Median 42.0 38.0
Peripheral blast
 Min.–Max. 10.0–82.0 0.0–87.0 U = 249.0 0.928
 Mean ± SD 37.09 ± 24.16 36.35 ± 24.65
 Median 34.0 30.0
Bone marrow blast
 Min.–Max. 40.0–92.0 30.0–99.0 t = 1.042 0.303
 Mean ± SD 72.32 ± 16.59 66.61 ± 19.93
 Median 75.0 67.0
NO level 2.79–46.9 3.2–60.9 0.931 0.352
14.17 (16.30) 12.20 (12.27)
Remission Status
 Responders (CR and PR) 9 40.9 8 34.8 χ2 = 0.331 MCp = 0.924
 Refractory 4 18.2 4 17.4
 Died 9 40.9 11 47.8
Mortality
 Alive 7 31.8 7 30.4 χ2 = 0.010 0.920
 Died 15 68.2 16 69.6   
Duration of survival
 Min.–Max. 10.0–90.0 10.0–90.0 U = 223.0 0.489
 Mean ± SD 49.18 ± 31.53 45.0 ± 32.02
 Median 37.50 37.0
  1. χ2, p: χ2 and P values for chi-square test
  2. MCp: P value for Monte Carlo for chi-square test
  3. U, p: U and p values for Mann-Whitney test
  4. t, p: t and p values for Student t test