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Table 4 Comparison between low and high DNMT3a gene expressors with respect to their demographics as well as clinical data

From: Prognostic significance of DNMT3a gene expression and reactive nitrogen species in newly diagnosed Egyptian de novo adult acute myeloid leukemia patients

 

Level of expression

Test of sig.

p

 

Low expression

(n = 22)

High expression

(n = 23)

 

No.

%

No.

%

Sex

 Male

12

54.5

12

52.2

χ2 = 0.025

0.873

 Female

10

45.5

11

47.8

Age (years)

 Min.–Max.

20.0–72.0

20.0–78.0

t = 0.754

0.455

 Mean ± SD

44.05 ± 14.85

47.70 ± 17.47

 Median

42.50

53.0

Co-Morbidities

 None

16

72.7

14

60.9

χ2 = 0.927

MCp = 0.743

 Single

4

18.2

5

21.7

 Multiple

2

9.1

4

17.4

Cytogenetic

 Poor risk

4

57.1

3

42.9

χ2 = 3.012

MCp = 0.248

 Intermediate risk

15

60

10

40

 Good risk

4

44.4

9

55.6

Total leucocyte count

 Min.–Max.

1.0–152.0

1.0–236.0

U = 217.50

0.419

 Mean ± SD.

27.59 ± 37.82

45.48 ± 76.04

 Median

11.0

6.0

Hemoglobin

 Min.–Max.

4.0–12.0

5.0–12.0

t = 0.771

0.445

 Mean ± SD

7.27 ± 1.98

7.74 ± 2.07

 Median

8.0

8.0

Platelets

 Min.–Max

4.0–345.0

4.0–248.0

U = 242.50

0.812

 Mean ± SD

68.18 ± 80.60

60.91 ± 64.05

 Median

42.0

38.0

Peripheral blast

 Min.–Max.

10.0–82.0

0.0–87.0

U = 249.0

0.928

 Mean ± SD

37.09 ± 24.16

36.35 ± 24.65

 Median

34.0

30.0

Bone marrow blast

 Min.–Max.

40.0–92.0

30.0–99.0

t = 1.042

0.303

 Mean ± SD

72.32 ± 16.59

66.61 ± 19.93

 Median

75.0

67.0

NO level

2.79–46.9

3.2–60.9

0.931

0.352

14.17 (16.30)

12.20 (12.27)

Remission Status

 Responders (CR and PR)

9

40.9

8

34.8

χ2 = 0.331

MCp = 0.924

 Refractory

4

18.2

4

17.4

 Died

9

40.9

11

47.8

Mortality

 Alive

7

31.8

7

30.4

χ2 = 0.010

0.920

 Died

15

68.2

16

69.6

  

Duration of survival

 Min.–Max.

10.0–90.0

10.0–90.0

U = 223.0

0.489

 Mean ± SD

49.18 ± 31.53

45.0 ± 32.02

 Median

37.50

37.0

  1. χ2, p: χ2 and P values for chi-square test
  2. MCp: P value for Monte Carlo for chi-square test
  3. U, p: U and p values for Mann-Whitney test
  4. t, p: t and p values for Student t test