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Table 1 Number of copies of SMN1 and SMN2 genes in the Venezuelan population sample

From: Spinal muscular atrophy in Venezuela: quantitative analysis of SMN1 and SMN2 genes

GeneEstimated number of copiesRanges of values ​of 2−ΔΔCTSDNumber of individuals (n = 49)Frequency (%)
SMN110.35-12.0
1 or 2 (*)0.66–0.72-612.2
20.83–1.100.143775.5
31.36–1.380.0124.1
4 or 52.42–2.880.2324.1
6 or 73.30-12.0
SMN200-816.3
10.26–0.530.132755.1
1 or 2 (*)0.67–0.74-24.1
20.82–1.200.19714.3
31.35–1.700.18510.2
  1. The relative gene copy numbers were estimated by the 2−ΔΔCT expression (Livak’s method) [8]; for two gene copies, its value is expected to be around 1; in deletion carriers (one gene copy), it is about 0.5, and in homozygous deletion individuals, it is 0
  2. SD standard deviation
  3. *Uncertain values for classification of gene copy numbers