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Table 2 Comparison between low and high LEF-1 expression groups regarding clinical data, laboratory data, and cytogenetic classification

From: Lymphoid enhancer-binding factor 1 (LEF-1): a favorable prognostic factor in adult acute myeloid leukemia in Egyptian patients

ParametersLEF1Test of significance
Low expression < 4.82 log10N = 15High expression > 4.82 log10N = 15
Mean/NSD/%Mean/NSD/%Testp valueSig.
Age61.0± 10.237.7± 8.4t = 6.82< 0.001HS
SexMale960.0%853.3%F0.713NS
Female640.0%746.7%
HepatomegalyNo533.3%1386.7%X2 = 8.80.003HS
Yes1066.7%213.3%
SplenomegalyNo746.7%1280.0%X2 = 3.50.058NS
Yes853.3%320.0%
Lymph-adenopathyNo1066.7%1280.0%F0.682NS
Yes533.3%320.0%
Hb (g/dL)6.9± 2.29.4± 1.4t = − 3.70.001HS
TLC (× 109/L)71.0± 53.19.5± 5.5t = 4.460.001HS
PLT (× 109/L)32.8± 14.282.0± 35.2t = − 5.0< 0.001HS
PB blast (%)52.1± 28.319.5± 10.6t = 4.190.001HS
BM blast (%)70.9± 21.274.9± 20.5t = − 0.50.603NS
Cytogenetics classificationPoor426.7%00.0%F0.015S
Intermediate960.0%746.7%
Good213.3%853.3%
Response to therapy at day 28Hematological Remission00.0%960.0%F< 0.001HS
Incomplete Remission746.7%640.0%
Died853.3%00.0%
Overall survival (months)2.75± 2.006.40± 2.59t = 4.52< 0.001HS
Disease free survival (months)--5.9± 2.5   
  1. N number, Hb hemoglobin, TLC total leucocytic count, PB peripheral blood, BM bone marrow, LEF-1 lymphoid enhancer binding factor 1, t student’s t test, F Fisher’s exact test, X2 Chi square test, S significant, HS highly significant, NS non-significant